H2AFX and KAT5

Number of citations of the paper that reports this interaction (PMID 18406329)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		H2AFX	KAT5
Gene Name		H2A histone family, member X	K(lysine) acetyltransferase 5
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Nuclear Chromatin Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Site Of Double-strand Break Extracellular Vesicular Exosome	Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Protein Complex Binding Metal Ion Binding Androgen Receptor Binding Repressing Transcription Factor Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Positive Regulation Of DNA Repair Meiotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Chromatin Organization Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Viral Process Histone Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Acetylation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends RNF mutants show enhanced WNT signaling and proliferation Homologous recombination repair of replication-independent double-strand breaks ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance ATM mediated response to DNA double-strand break misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Chromatin organization formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Senescence-Associated Secretory Phenotype (SASP) Chromatin modifying enzymes Recruitment of repair and signaling proteins to double-strand breaks SIRT1 negatively regulates rRNA Expression Condensation of Prophase Chromosomes MRN complex relocalizes to nuclear foci RNA Polymerase I Promoter Clearance Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks M Phase Telomere Maintenance Nucleosome assembly XAV939 inhibits tankyrase, stabilizing AXIN Double-Strand Break Repair DNA methylation Transcriptional regulation by small RNAs Meiotic recombination RNA Polymerase I Transcription Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic PRC2 methylates histones and DNA RMTs methylate histone arginines TCF dependent signaling in response to WNT Oxidative Stress Induced Senescence Homologous Recombination Repair RNA Polymerase I Promoter Opening Signaling by WNT in cancer	Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146)
Protein-Protein Interactions		45 interactors: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 KAT5 MASP1 MCPH1 MDC1 MRE11A NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PPP2R4 PRKDC QARS RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TSSK6 WRN XRCC6	136 interactors: ALOX12 APBB1 APLP1 APLP2 APP AR ARIH2 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CREB1 CREBBP CRELD1 CSTF2 DLEU1 DUSP23 E2F1 EDNRA EFNA1 EP300 ESR1 ESR2 ETV6 FAM101B FAM135B FAM173A GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL1P1 GOLGA2 GSTO1 H2AFX H3F3B HABP4 HAP1 HDAC1 HDAC7 HIST1H3A HIST1H4A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMBOX1 HNRNPH3 IK IKZF3 IL9R KIAA1377 KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PHC2 PIH1D3 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RGL2 RRM1 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513
Entrez ID		3014	10524
HPRD ID		03465	03245
Ensembl ID		ENSG00000188486	ENSG00000172977
Uniprot IDs		P16104	Q92993
PDB IDs		2D31 2DYP 3SHV 3SQD 3SZM 3U3Z	2EKO 2OU2
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Organization DNA Recombination Organelle Organization Cellular Response To Stress Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Chromatin Organization Response To Stress Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Modification Signal Transduction By P53 Class Mediator Response To Stimulus Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Cellular Response To Stimulus Cellular Protein Modification Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification DNA Damage Checkpoint Peptidyl-lysine Modification Cell Cycle Process Regulation Of Cellular Protein Metabolic Process DNA Replication Regulation Of Gene Expression Response To Gamma Radiation Negative Regulation Of Protein Metabolic Process Histone Acetylation Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Mitotic Cell Cycle Chromosome Organization Anatomical Structure Development Cellular Macromolecule Biosynthetic Process System Development Tissue Development Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cell Death Apoptotic Process Death Organelle Organization Programmed Cell Death Biosynthetic Process
Tagcloud ?			accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?			accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
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