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H2AFX and TSSK6
Number of citations of the paper that reports this interaction (PMID
15870294
)
14
Data Source:
BioGRID
(enzymatic study)
H2AFX
TSSK6
Gene Name
H2A histone family, member X
testis-specific serine kinase 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Nucleus
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Protein Phosphorylation
Multicellular Organismal Development
Regulation Of Signal Transduction
Sperm Chromatin Condensation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
8 interactors:
APP
H2AFX
HIST1H3A
HIST2H2AC
HSP90AB1
HSPA1A
HSPA8
MBP
Entrez ID
3014
83983
HPRD ID
03465
15441
Ensembl ID
ENSG00000188486
ENSG00000178093
Uniprot IDs
P16104
Q9BXA6
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Cellular Response To Heat
Cellular Response To Heat
Response To Heat
Response To Unfolded Protein
Response To Stress
Response To Abiotic Stimulus
Protein Refolding
Response To Temperature Stimulus
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Protein Folding
Response To External Stimulus
Axon Guidance
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Fibril Organization
Locomotion
Axonogenesis
MRNA Metabolic Process
Cellular Heat Acclimation
Synaptic Growth At Neuromuscular Junction
Axon Development
Nucleosome Assembly
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Chromatin Assembly
Cellular Response To Stress
Defense Response To Nematode
Collateral Sprouting In Absence Of Injury
Regulation Of Fibril Organization
Neuron Projection Morphogenesis
Nucleosome Organization
Generation Of Neurons
Regulation Of Protein Binding
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Neurogenesis
Cell Morphogenesis Involved In Differentiation
Collateral Sprouting
Axon Midline Choice Point Recognition
Clathrin Coat Disassembly
DNA Packaging
Negative Regulation Of Neuron Differentiation
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Intracellular Receptor Signaling Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Neuron Projection Development
Cell Projection Morphogenesis
Axon Choice Point Recognition
Response To Nematode
Cell Part Morphogenesis
Negative Regulation Of Protein Metabolic Process
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Tagcloud (Intersection)
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