H2AX and MRE11

Number of citations of the paper that reports this interaction (PubMedID 15201865)
37

Data Source:
BioGRID (imaging technique, affinity chromatography technology, imaging technique, affinity chromatography technology)
HPRD (in vivo, in vitro)

		H2AX	MRE11
Description		H2A.X variant histone	MRE11 double strand break repair nuclease
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleosome Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Chromosome Centrosome Nuclear Speck Site Of Double-strand Break Extracellular Exosome Site Of DNA Damage	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break BRCA1-C Complex Chromosomal Region
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Structural Constituent Of Chromatin Histone Binding Protein Heterodimerization Activity Chromatin-protein Adaptor Activity	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair DNA Recombination Nucleosome Assembly DNA Damage Response Spermatogenesis Response To Ionizing Radiation Heterochromatin Formation Positive Regulation Of DNA Repair Meiotic Cell Cycle Protein K63-linked Ubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Signaling Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Chromosome Organization Meiotic Cell Cycle R-loop Processing Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Interacting Genes		47 interacting genes: A2M ACTB ALG9 ATM ATR BAZ1B BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 CTBP1 DDX21 EYA1 GRB2 HDAC6 HUWE1 KAT5 MAPK8 MASP1 MDC1 MRE11 MUC1 NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PRKDC PTEN PTPA QARS1 RNF8 RPS6KA3 SMARCA4 SUPT5H TAF1C TAF5L TERF2 TIAM2 TP53BP1 TRAF6 TSSK6 WRN	27 interacting genes: ATM ATR CCNE1 CDK2 CDX2 CEBPA DCLRE1C DYNLL1 EP300 FANCD2 GRB2 H1-2 H2AX H4C1 LIG1 LOX MAPK8IP2 NBN NEK1 NKX3-1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6
Entrez ID		3014	4361
HPRD ID		03465	02889
Ensembl ID		ENSG00000188486	ENSG00000020922
Uniprot IDs		P16104	F8W7U8 P49959 Q05D78
PDB IDs		1YDP 2AZM 2D31 2DYP 3SHV 3SQD 3SZM 3U3Z 6K1I 6K1J 6K1K 6ZWK 7YQK	3T1I 7ZQY 8BAH 8K00
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Regulation Of DNA Repair DNA Damage Response Signal Transduction In Response To DNA Damage Positive Regulation Of DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromatin Remodeling Regulation Of DNA Metabolic Process DNA Repair Double-strand Break Repair Protein Localization To Site Of Double-strand Break Response To Ionizing Radiation Regulation Of Double-strand Break Repair Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Repair Regulation Of Cell Cycle Process Protein Localization To Chromosome Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Chromosome, Telomeric Region Regulation Of Primary Metabolic Process Intracellular Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA Recombination Nucleic Acid Metabolic Process Positive Regulation Of Double-strand Break Repair DNA Damage Checkpoint Signaling Telomere Maintenance Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Chromosome Positive Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Stress Telomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Nucleus Negative Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling	DNA Damage Response Telomere Organization DNA Metabolic Process Telomere Maintenance Chromosome Organization DNA Repair Double-strand Break Repair DNA Strand Resection Involved In Replication Fork Processing Chromosome, Telomeric Region Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage DNA Recombination DNA Damage Checkpoint Signaling Protein Localization To Chromosome Histone H2AXS139 Kinase Activity Organelle Organization Negative Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Recombinational Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Negative Regulation Of Cell Cycle Somatic Cell DNA Recombination Regulation Of DNA Metabolic Process V(D)J Recombination Negative Regulation Of Cell Cycle Process Chromosome Response To Gamma Radiation Regulation Of Cell Cycle Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Process Response To Radiation Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Response To Stress Mitotic DNA Integrity Checkpoint Signaling Regulation Of DNA Recombination Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Capping Nonhomologous End Joining Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle
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