NGFR and EGR1

Number of citations of the paper that reports this interaction (PubMedID 18378044)
46

Data Source:
BioGRID (pull down)

		NGFR	EGR1
Description		nerve growth factor receptor	early growth response 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Enzyme Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Estrous Cycle Locomotor Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Rhythmic Process Circadian Temperature Homeostasis Interleukin-1-mediated Signaling Pathway Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-8 Positive Regulation Of Post-translational Protein Modification Positive Regulation Of MiRNA Transcription Regulation Of Progesterone Biosynthetic Process
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription NGF-stimulated transcription Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 28991256)
Interacting Genes		50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	27 interacting genes: CDKN2A CEBPB CRBN CREBBP CSNK2A1 DNMT3L EP300 ERBB3 IL1B JUN MTDH NAB1 NAB2 NEAT1 NEDD4 NFATC1 NFATC2 NGFR PITX1 PSMA3 RELA SNCA SP1 SRA1 SREBF2 TP53 WT1
Entrez ID		4804	1958
HPRD ID		01197	00549
Ensembl ID		ENSG00000064300	ENSG00000120738
Uniprot IDs		P08138	P18146 Q546S1
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T	4R2A 4R2C 4R2D 4X9J 5N14
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation	Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Intracellular Signaling Cassette Transcription Regulator Complex Regulation Of Developmental Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Signal Transduction Chromatin DNA-binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Schwann Cell Differentiation NF-kappaB Binding Cellular Response To Stress Regulation Of Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?