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H2AFX and PRKDC
Number of citations of the paper that reports this interaction (PMID
22184063
)
5
Data Source:
BioGRID
(enzymatic study)
H2AFX
PRKDC
Gene Name
H2A histone family, member X
protein kinase, DNA-activated, catalytic polypeptide
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Nonhomologous End Joining Complex
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Enzyme Binding
Poly(A) RNA Binding
Biological Process
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Somitogenesis
Negative Regulation Of Protein Phosphorylation
B Cell Lineage Commitment
Pro-B Cell Differentiation
T Cell Lineage Commitment
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Protein Modification Process
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Peptidyl-serine Phosphorylation
Protein Destabilization
Positive Regulation Of Type I Interferon Production
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Ectopic Germ Cell Programmed Cell Death
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Nonhomologous End-joining (NHEJ)
Cytosolic sensors of pathogen-associated DNA
Processing of DNA ends prior to end rejoining
STING mediated induction of host immune responses
Double-Strand Break Repair
IRF3-mediated induction of type I IFN
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
83 interactors:
ABL1
AICDA
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CHEK1
CHEK2
CHUK
CIB1
CTDP1
DCLRE1C
E4F1
EIF2S2
EIF4EBP1
ERG
GSK3A
GSK3B
GZMB
H2AFX
HDAC3
HIST1H1A
HIST1H1C
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11A
NBN
NCF1
NCF2
NCF4
NCOA6
NR3C1
PARP1
PCNA
PDX1
PGR
POU2F1
PPP6C
PPP6R1
PPP6R2
PPP6R3
PRKCD
PTS
RAD17
RBBP8
RNF144A
RPA1
RPA2
SGOL1
SP1
SRF
THRA
THRB
TP53
TREX1
UBC
USF1
VPRBP
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
Entrez ID
3014
5591
HPRD ID
03465
02941
Ensembl ID
ENSG00000188486
ENSG00000253729
Uniprot IDs
P16104
P78527
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To Stress
DNA Repair
Cellular Response To DNA Damage Stimulus
DNA Recombination
DNA Metabolic Process
Double-strand Break Repair
Response To Stress
Immune System Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Apoptotic Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Response To Abiotic Stimulus
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Response To Organic Substance
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Immune System Development
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Cell Cycle
Cellular Response To Organic Substance
Regulation Of Nitrogen Compound Metabolic Process
Apoptotic Process
Organelle Organization
Cellular Metabolic Process
Programmed Cell Death
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cell Cycle Process
Cell Death
Death
Telomere Maintenance
Developmental Process
Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter
Intrinsic Apoptotic Signaling Pathway
DNA Damage Checkpoint
Cellular Macromolecule Biosynthetic Process
Response To Stimulus
Mitotic Cell Cycle
Macromolecule Biosynthetic Process
Response To Radiation
Organ Development
Mitotic Cell Cycle Process
Tagcloud
?
1ada
1p24
antiretroviral
atazanavir
atv
boosted
capacities
carriage
coating
depots
fa
folic
il2rg
loads
mirrored
nanoart
nanocrystals
nanoformulated
p407
parafollicular
paralleled
permit
pharmacodynamic
poloxamer
reconstituted
ritonavir
szj
tm1wjl
untargeted
Tagcloud (Difference)
?
1ada
1p24
antiretroviral
atazanavir
atv
boosted
capacities
carriage
coating
depots
fa
folic
il2rg
loads
mirrored
nanoart
nanocrystals
nanoformulated
p407
parafollicular
paralleled
permit
pharmacodynamic
poloxamer
reconstituted
ritonavir
szj
tm1wjl
untargeted
Tagcloud (Intersection)
?