Wiki-Pi
About
Search
People
Updates
Search
NGFR and NTRK1
Number of citations of the paper that reports this interaction (PubMedID
9927421
)
41
Data Source:
HPRD
(in vivo)
NGFR
NTRK1
Description
nerve growth factor receptor
neurotrophic receptor tyrosine kinase 1
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cell-cell Junction
Cell Surface
Postsynaptic Density
Membrane
Growth Cone
Neuromuscular Junction
Cell Projection
Dendritic Spine
Perikaryon
Organelle
Synapse
Presynapse
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Late Endosome
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome
Recycling Endosome Membrane
Molecular Function
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
Death Receptor Activity
Protein Binding
Calmodulin Binding
Coreceptor Activity
Small GTPase Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Activity
Transferase Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Biological Process
Intracellular Glucose Homeostasis
Hair Follicle Development
Intracellular Protein Transport
Apoptotic Process
Signal Transduction
Rho Protein Signal Transduction
Nervous System Development
Axon Guidance
Central Nervous System Development
Circadian Rhythm
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Gene Expression
Detection Of Temperature Stimulus
Nerve Development
Cell Differentiation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Circadian Regulation Of Gene Expression
Dorsal Aorta Development
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Skin Development
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Neuron Apoptotic Process
Negative Regulation Of Hair Follicle Development
Extrinsic Apoptotic Signaling Pathway
Presynaptic Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Cellular Response To Amyloid-beta
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Apoptotic Signaling Pathway
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Nervous System Development
Axon Guidance
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
Cell Differentiation
B Cell Differentiation
Neuron Projection Development
Response To Nutrient Levels
Response To Nicotine
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Sympathetic Nervous System Development
Neuron Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neuron Apoptotic Process
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Innervation
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Growth Factor Stimulus
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Pathways
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Diseases
Neuroblastoma
Thyroid cancer
GWAS
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Lower body strength (
27325353
)
Mean spheric corpuscular volume (
32888494
)
Prostate cancer (
23535732
)
Red cell distribution width (
32888494
)
Interacting Genes
50 interacting genes:
ANXA7
APP
BEX1
BEX3
BNIP3L
CAV1
CD80
CDKN1A
EGR1
FSCN1
GRB2
H2AX
IL2
KIDINS220
LINGO1
MAG
MAGED1
MAGEH1
MAPK1
MAPK3
MDM2
NDN
NFKBIB
NGF
NSMCE3
NTF4
NTRK1
NTRK2
NTRK3
PRKACB
PTPN13
RCC1
RIPK2
RPN2
RTN4R
SHC1
SMN1
SORT1
STMN2
TK1
TP53
TRA2B
TRADD
TRAF2
TRAF4
TRAF6
TRIM37
TTR
UFD1
ZNF274
41 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
HIPK2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
Entrez ID
4804
4914
HPRD ID
01197
01869
Ensembl ID
ENSG00000064300
ENSG00000198400
Uniprot IDs
P08138
P04629
X5DR71
PDB IDs
2N80
2N83
2N97
3EWV
5ZGG
7CSQ
8X8T
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
7N3T
7VKM
7VKN
7VKO
7XAF
7XBI
8J5W
8J5X
8J61
8J63
8YTD
8YTE
Enriched GO Terms of Interacting Partners
?
Neurotrophin Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Nerve Growth Factor Signaling Pathway
Regulation Of Apoptotic Process
Response To Growth Factor
Signal Transduction
Response To Nerve Growth Factor
Regulation Of Protein Metabolic Process
Protein-containing Complex
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Protein Modification Process
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of MAPK Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Intracellular Signal Transduction
Enzyme Binding
Apoptotic Process
Regulation Of Multicellular Organismal Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Programmed Cell Death
Cell Death
Identical Protein Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of MAPK Cascade
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Receptor Activity
Neurotrophin Binding
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Growth Factor Stimulus
Signaling Adaptor Activity
Regulation Of Gene Expression
Regulation Of Cellular Component Organization
Circadian Rhythm
Regulation Of Macromolecule Biosynthetic Process
Caveolin-mediated Endocytosis
Nerve Growth Factor Receptor Binding
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Cytokine-mediated Signaling Pathway
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Myelination
Apoptotic Signaling Pathway
Axon Ensheathment
Regulation Of Cell Projection Organization
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Programmed Cell Death
Response To Radiation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Phosphotyrosine Residue Binding
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytosol
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
ERBB Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Neurotrophin TRKA Receptor Binding
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Insulin Receptor Binding
Neurotrophin Signaling Pathway
Plasma Membrane
Regulation Of Apoptotic Process
Nerve Growth Factor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Regulation Of Programmed Cell Death
Intracellular Signaling Cassette
Signaling Adaptor Activity
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Population Proliferation
Ephrin Receptor Binding
Protein Kinase Binding
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune Response
Positive Regulation Of D-glucose Import
Regulation Of Cell Adhesion
Enzyme Binding
Regulation Of Cellular Localization
SH2 Domain Binding
Insulin-like Growth Factor Receptor Binding
Developmental Process
Positive Regulation Of D-glucose Transmembrane Transport
Regulation Of Biological Quality
Negative Regulation Of Programmed Cell Death
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?