NGFR and SORT1

Number of citations of the paper that reports this interaction (PMID 14985763)
143

Data Source:
HPRD (in vivo)

		NGFR	SORT1
Gene Name		nerve growth factor receptor	sortilin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density	Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G-protein Coupled Nerve Growth Factor Binding
	Biological Process	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus	Ossification Golgi To Endosome Transport Endocytosis G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organismal Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity
Pathways		Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)	Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Coronary heart disease ( 21378988 21378990) LDL cholesterol ( 18193043 18193044 19060906 19060910 20686565) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Progranulin levels ( 21087763) Response to statin therapy ( 20339536)
Protein-Protein Interactions		45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274	8 interactors: BDNF GGA1 GGA2 LRPAP1 NGF NGFR NTS SORCS1
Entrez ID		4804	6272
HPRD ID		01197	03910
Ensembl ID		ENSG00000064300	ENSG00000134243
Uniprot IDs		P08138	Q99523
PDB IDs		3EWV	3F6K 3G2U 3G2V
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Regulation Of Axonogenesis Circadian Rhythm Cellular Response To Nerve Growth Factor Stimulus Response To Electrical Stimulus Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Regulation Of Axon Extension Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Response To Anesthetic Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Fluoxetine Response To L-glutamate Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Nerve Development Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Regulation Of Stem Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Size Taste Bud Development Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Neuron Maturation Dendrite Extension Negative Regulation Of Hair Follicle Development Cellular Response To Norepinephrine Stimulus Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Hair Cycle Nerve Growth Factor Processing Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Apoptotic Process Axon Target Recognition Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Response To Norepinephrine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Response To Ether Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Death Regulation Of Cysteine-type Endopeptidase Activity Cell Projection Morphogenesis
Tagcloud ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified
Tagcloud (Difference) ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	aaa acceptance adequately advances aneurysm avenues bioinformatics chances collaboration confirmatory considerable decade difficulty exploration focusing highlighted identification ldlr lrp1 millions necessity original owing powered progressed robustly unlock variant verified
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