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H2AX and TP53BP1
Number of citations of the paper that reports this interaction (PubMedID
12447390
)
0
Data Source:
HPRD
(in vivo)
H2AX
TP53BP1
Description
H2A.X variant histone
tumor protein p53 binding protein 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleosome
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Centrosome
Nuclear Speck
Site Of Double-strand Break
Extracellular Exosome
Site Of DNA Damage
Chromosome, Centromeric Region
Kinetochore
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Cytoplasm
Nuclear Body
Site Of Double-strand Break
DNA Repair Complex
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Structural Constituent Of Chromatin
Histone Binding
Protein Heterodimerization Activity
Chromatin-protein Adaptor Activity
P53 Binding
DNA Binding
Damaged DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
Telomeric DNA Binding
Histone Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin-modified Histone Reader Activity
Histone H4K20me2 Reader Activity
Histone Reader Activity
Histone H4K20me Methyltransferase Activity
Biological Process
DNA Damage Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
DNA Recombination
Nucleosome Assembly
DNA Damage Response
Spermatogenesis
Response To Ionizing Radiation
Heterochromatin Formation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Protein K63-linked Ubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
DNA Damage Checkpoint Signaling
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
DNA Damage Response
Positive Regulation Of Isotype Switching
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Protein Homooligomerization
Cellular Response To X-ray
Double-strand Break Repair Via Classical Nonhomologous End Joining
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
SUMOylation of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Antibody level in response to infection (
25758998
)
Apolipoprotein A1 levels (
32203549
)
Cardiometabolic and hematological traits (
27668658
)
Eosinophil count (
32888494
)
HDL cholesterol levels (
32203549
30698716
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Lipoprotein phospholipase A2 activity in cardiovascular disease (
28753643
)
Liver volume (
34128465
)
Lung cancer in ever smokers (
28604730
)
Mean corpuscular volume (
32888494
)
Triglyceride levels (
30698716
)
Triglyceride levels in current drinkers (
30698716
)
Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Triglycerides (
27036123
)
Interacting Genes
47 interacting genes:
A2M
ACTB
ALG9
ATM
ATR
BAZ1B
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
CTBP1
DDX21
EYA1
GRB2
HDAC6
HUWE1
KAT5
MAPK8
MASP1
MDC1
MRE11
MUC1
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PRKDC
PTEN
PTPA
QARS1
RNF8
RPS6KA3
SMARCA4
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TP53BP1
TRAF6
TSSK6
WRN
60 interacting genes:
ANKS1A
ARAP1
ATM
BCL6
BLM
BRCA1
BRCA2
C10orf55
CCDC120
CCNB1
CDK1
CEBPA
CHEK1
CRB2
CREB5
DCLRE1A
DCLRE1C
DYNLL1
E2F1
EP300
GALNTL5
H2AC4
H2AX
H4C1
H4C14
H4C16
HGS
IFI16
KAT8
KDM1A
KLHDC7B
LIG4
MDC1
MEOX2
NCOA3
NEK1
NFKB1
NUDT16
OXER1
PARP1
PAXIP1
PCNT
PITX1
POU6F2
PTEN
RAD18
RAD50
RAD51
RBL1
RBL2
RELA
SPAG9
SPOP
SUMO2
TFDP1
TLX3
TP53
UBAP2
USP28
VAC14
Entrez ID
3014
7158
HPRD ID
03465
05569
Ensembl ID
ENSG00000188486
ENSG00000067369
Uniprot IDs
P16104
A6NNK5
Q12888
PDB IDs
1YDP
2AZM
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
6K1I
6K1J
6K1K
6ZWK
7YQK
1GZH
1KZY
1XNI
2G3R
2IG0
2LVM
2MWO
2MWP
3LGF
3LGL
3LH0
4CRI
4RG2
4X34
5ECG
5J26
5KGF
5Z78
5ZCJ
6CO1
6CO2
6IU7
6IUA
6MXX
6MXY
6MXZ
6MY0
6RML
6RMM
6UPT
6VA5
6VIP
7LIN
7LIO
7YQK
8EOM
8F0W
8HKW
8SVG
8SVH
8SVI
8SVJ
8SWJ
8T2D
8U4U
9CKJ
Enriched GO Terms of Interacting Partners
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Regulation Of Cellular Response To Stress
Regulation Of DNA Repair
DNA Damage Response
Signal Transduction In Response To DNA Damage
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA Metabolic Process
DNA Repair
Double-strand Break Repair
Protein Localization To Site Of Double-strand Break
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Cellular Response To Stress
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Repair
Regulation Of Cell Cycle Process
Protein Localization To Chromosome
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Chromosome, Telomeric Region
Regulation Of Primary Metabolic Process
Intracellular Signal Transduction
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of DNA Recombination
Nucleic Acid Metabolic Process
Positive Regulation Of Double-strand Break Repair
DNA Damage Checkpoint Signaling
Telomere Maintenance
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Chromosome
Positive Regulation Of DNA Recombination
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Response To Stress
Telomere Organization
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Phase Transition
Mitotic DNA Damage Checkpoint Signaling
Response To Ionizing Radiation
Chromatin Organization
Chromosome
Regulation Of Cell Cycle Phase Transition
DNA Damage Response
Chromosome, Telomeric Region
Regulation Of Cell Cycle Process
Nucleoplasm
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Phase Transition
Chromatin Remodeling
Negative Regulation Of Cell Cycle
DNA Repair
Signal Transduction In Response To DNA Damage
DNA Metabolic Process
Regulation Of Cell Cycle
Cellular Response To Radiation
DNA Binding
Response To Radiation
DNA Damage Checkpoint Signaling
Regulation Of DNA Recombination
Cellular Response To Ionizing Radiation
Protein Localization To Chromosome
Cellular Response To Stress
Negative Regulation Of Mitotic Cell Cycle
Regulation Of DNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Double-strand Break Repair
Telomere Organization
DNA Recombination
Nucleus
Transcription Regulator Complex
Site Of Double-strand Break
Protein-containing Complex
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Nucleic Acid Metabolic Process
Chromosome Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Chromatin
Regulation Of Cell Cycle G2/M Phase Transition
Response To X-ray
Regulation Of Macromolecule Metabolic Process
Response To Gamma Radiation
Replication Fork
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Primary Metabolic Process
Signal Transduction By P53 Class Mediator
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Tagcloud (Difference)
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Tagcloud (Intersection)
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