H2AFX and TP53BP1

Number of citations of the paper that reports this interaction (PMID 12447390)
151

Data Source:
HPRD (in vivo)

		H2AFX	TP53BP1
Gene Name		H2A histone family, member X	tumor protein p53 binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Nuclear Chromatin Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Site Of Double-strand Break Extracellular Vesicular Exosome	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Cofactor Activity P53 Binding Damaged DNA Binding Protein Binding Methylated Histone Binding Telomeric DNA Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Positive Regulation Of DNA Repair Meiotic Cell Cycle	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends RNF mutants show enhanced WNT signaling and proliferation Homologous recombination repair of replication-independent double-strand breaks ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance ATM mediated response to DNA double-strand break misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Chromatin organization formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Senescence-Associated Secretory Phenotype (SASP) Chromatin modifying enzymes Recruitment of repair and signaling proteins to double-strand breaks SIRT1 negatively regulates rRNA Expression Condensation of Prophase Chromosomes MRN complex relocalizes to nuclear foci RNA Polymerase I Promoter Clearance Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks M Phase Telomere Maintenance Nucleosome assembly XAV939 inhibits tankyrase, stabilizing AXIN Double-Strand Break Repair DNA methylation Transcriptional regulation by small RNAs Meiotic recombination RNA Polymerase I Transcription Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic PRC2 methylates histones and DNA RMTs methylate histone arginines TCF dependent signaling in response to WNT Oxidative Stress Induced Senescence Homologous Recombination Repair RNA Polymerase I Promoter Opening Signaling by WNT in cancer	Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 KAT5 MASP1 MCPH1 MDC1 MRE11A NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PPP2R4 PRKDC QARS RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TSSK6 WRN XRCC6	34 interactors: ARAP1 ATM BLM BRCA1 CCNB1 CDK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AFX HIST1H4A HIST2H4A HIST4H4 IFI16 LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 PAXIP1 PCNT PLK1 RAD18 RELA SPAG9 TFDP1 TP53 USP28 VAC14
Entrez ID		3014	7158
HPRD ID		03465	05569
Ensembl ID		ENSG00000188486	ENSG00000067369
Uniprot IDs		P16104	F8VY86 Q12888
PDB IDs		2D31 2DYP 3SHV 3SQD 3SZM 3U3Z	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Organization DNA Recombination Organelle Organization Cellular Response To Stress Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Chromatin Organization Response To Stress Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Modification Signal Transduction By P53 Class Mediator Response To Stimulus Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Cellular Response To Stimulus Cellular Protein Modification Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification DNA Damage Checkpoint Peptidyl-lysine Modification Cell Cycle Process Regulation Of Cellular Protein Metabolic Process DNA Replication Regulation Of Gene Expression Response To Gamma Radiation Negative Regulation Of Protein Metabolic Process Histone Acetylation Double-strand Break Repair Via Nonhomologous End Joining	Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Process DNA Damage Checkpoint DNA Metabolic Process Response To Abiotic Stimulus Response To Radiation Mitotic Cell Cycle Process Cell Cycle Checkpoint DNA Repair Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Response To Stress Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cell Death Telomere Maintenance Death Apoptotic Signaling Pathway DNA Recombination Intracellular Signal Transduction Regulation Of Metabolic Process G2 DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Phase Transition Histone Modification Cell Cycle Phase Transition Apoptotic Process DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Programmed Cell Death DNA Packaging Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Difference) ?			abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Intersection) ?