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H2AFX and SUPT5H
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
H2AFX
SUPT5H
Gene Name
H2A histone family, member X
suppressor of Ty 5 homolog (S. cerevisiae)
Image
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
DSIF Complex
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Chromatin Binding
Protein Binding
Enzyme Binding
Poly(A) RNA Binding
Protein Heterodimerization Activity
Biological Process
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Remodeling
DNA-templated Transcription, Elongation
Transcription From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Cell Cycle
Response To Organic Substance
Gene Expression
Viral Process
Positive Regulation Of Macroautophagy
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Viral Transcription
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Formation of HIV-1 elongation complex containing HIV-1 Tat
RNA Polymerase II Transcription
Abortive elongation of HIV-1 transcript in the absence of Tat
mRNA Capping
HIV Infection
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Late Phase of HIV Life Cycle
Pausing and recovery of Tat-mediated HIV elongation
Formation of RNA Pol II elongation complex
HIV elongation arrest and recovery
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
Pausing and recovery of HIV elongation
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
HIV Transcription Elongation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
37 interactors:
C9orf78
CCNH
CCNT1
CCNT2
CDK7
CDK9
CSNK2A1
DBN1
DCAF6
GTF3C1
H2AFX
HTATSF1
IK
IKBKG
LMAN2
MAML3
MNAT1
PCBD1
PHYHIP
PIN1
PNO1
POLR2A
PPIA
PPP2R2D
PRMT1
PRMT5
SAP30BP
SIK1
SNX4
SSBP3
SUPT4H1
TERF1
XRCC5
ZBTB3
ZFYVE9
ZNF496
ZNF512B
Entrez ID
3014
6829
HPRD ID
03465
03655
Ensembl ID
ENSG00000188486
ENSG00000196235
Uniprot IDs
P16104
O00267
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
2DO3
2E6Z
2E70
3H7H
4L1U
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Viral Process
Transcription, DNA-templated
RNA Biosynthetic Process
DNA-templated Transcription, Elongation
Positive Regulation Of Viral Transcription
Viral Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Viral Transcription
Macromolecule Biosynthetic Process
Regulation Of Viral Process
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Cellular Nitrogen Compound Metabolic Process
DNA-templated Transcription, Initiation
Biosynthetic Process
Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Cell Cycle
Regulation Of Cellular Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
7-methylguanosine MRNA Capping
7-methylguanosine RNA Capping
Transcription From RNA Polymerase II Promoter
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of Metabolic Process
Cell Cycle
Cellular Metabolic Process
Nucleotide-excision Repair, DNA Damage Removal
Negative Regulation Of Gene Expression, Epigenetic
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Tagcloud
?
19q13
aa
acidic
argues
consensus
differ
end
family
homologue
lacks
like
map
maps
member
near
q
repeat
respond
ryanodine
seven
signals
similarity
spt5
spt6
terminus
unlike
w
yeast
Tagcloud (Difference)
?
19q13
aa
acidic
argues
consensus
differ
end
family
homologue
lacks
like
map
maps
member
near
q
repeat
respond
ryanodine
seven
signals
similarity
spt5
spt6
terminus
unlike
w
yeast
Tagcloud (Intersection)
?