NGFR and CDKN1A

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NGFR	CDKN1A
Description		nerve growth factor receptor	cyclin dependent kinase inhibitor 1A
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body Protein-containing Complex PCNA-p21 Complex
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine/threonine Kinase Binding Protein Sequestering Activity Molecular Function Activator Activity Molecular Function Inhibitor Activity
	Biological Process	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Protein Import Into Nucleus DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Response To UV Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Keratinocyte Differentiation Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Amino Acid Starvation Wound Healing Tissue Regeneration Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Programmed Cell Death Keratinocyte Proliferation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Negative Regulation Of Growth Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Import Into Nucleus Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Signal Transduction By P53 Class Mediator Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Neddylation Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs			Valproic acid Arsenic trioxide
Diseases			Cervical cancer
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Abdominal aortic aneurysm ( 32981348) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 30529582 31826910 22634755) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) JT interval ( 29874175) Left ventricle wall thickness ( 33495596) Left ventricular fractional shortening ( 28394258) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 31251759 31217584 30679814 27659466 27577874 25035420 21076409) Triglyceride levels ( 32203549) Triglycerides ( 27036123)
Interacting Genes		50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	207 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 NSUN2 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 POLD2 PPM1D PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RANBP9 RB1 RBBP4 RBM48 REL RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SCML2 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TNKS TRAF1 TRIM21 TRIM3 TRIM54 TRIM71 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431
Entrez ID		4804	1026
HPRD ID		01197	00298
Ensembl ID		ENSG00000064300	ENSG00000124762
Uniprot IDs		P08138	P38936
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T	1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H 7KQ0 7KQ1 8GJF
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation	Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Cytoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cyclin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Signal Transduction Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication
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