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NGFR and TRADD
Number of citations of the paper that reports this interaction (PubMedID
12604596
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
NGFR
TRADD
Description
nerve growth factor receptor
TNFRSF1A associated via death domain
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cell-cell Junction
Cell Surface
Postsynaptic Density
Membrane
Growth Cone
Neuromuscular Junction
Cell Projection
Dendritic Spine
Perikaryon
Organelle
Synapse
Presynapse
Tumor Necrosis Factor Receptor Superfamily Complex
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Death-inducing Signaling Complex
Receptor Complex
Molecular Function
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
Death Receptor Activity
Protein Binding
Calmodulin Binding
Coreceptor Activity
Small GTPase Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Kinase Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Identical Protein Binding
Molecular Adaptor Activity
Death Domain Binding
Biological Process
Intracellular Glucose Homeostasis
Hair Follicle Development
Intracellular Protein Transport
Apoptotic Process
Signal Transduction
Rho Protein Signal Transduction
Nervous System Development
Axon Guidance
Central Nervous System Development
Circadian Rhythm
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Gene Expression
Detection Of Temperature Stimulus
Nerve Development
Cell Differentiation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Circadian Regulation Of Gene Expression
Dorsal Aorta Development
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Skin Development
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Neuron Apoptotic Process
Negative Regulation Of Hair Follicle Development
Extrinsic Apoptotic Signaling Pathway
Presynaptic Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Cellular Response To Amyloid-beta
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Apoptotic Signaling Pathway
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Canonical NF-kappaB Signal Transduction
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Cell Migration
Tumor Necrosis Factor-mediated Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Inflammatory Response
Positive Regulation Of Hair Follicle Development
Cellular Response To Tumor Necrosis Factor
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Pathways
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
TNF signaling
Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Lower body strength (
27325353
)
Mean spheric corpuscular volume (
32888494
)
Prostate cancer (
23535732
)
Interacting Genes
50 interacting genes:
ANXA7
APP
BEX1
BEX3
BNIP3L
CAV1
CD80
CDKN1A
EGR1
FSCN1
GRB2
H2AX
IL2
KIDINS220
LINGO1
MAG
MAGED1
MAGEH1
MAPK1
MAPK3
MDM2
NDN
NFKBIB
NGF
NSMCE3
NTF4
NTRK1
NTRK2
NTRK3
PRKACB
PTPN13
RCC1
RIPK2
RPN2
RTN4R
SHC1
SMN1
SORT1
STMN2
TK1
TP53
TRA2B
TRADD
TRAF2
TRAF4
TRAF6
TRIM37
TTR
UFD1
ZNF274
24 interacting genes:
APBB2
BCL10
BIRC2
CNTRL
DAPK1
FADD
FAS
HIPK2
KRT14
KRT18
NGFR
PPP2R1A
RIPK1
STAT1
TMC8
TNFRSF10A
TNFRSF10B
TNFRSF1A
TNFRSF21
TNFRSF25
TRAF1
TRAF2
TRAF3
TRPC4AP
Entrez ID
4804
8717
HPRD ID
01197
04610
Ensembl ID
ENSG00000064300
ENSG00000102871
Uniprot IDs
P08138
Q15628
PDB IDs
2N80
2N83
2N97
3EWV
5ZGG
7CSQ
8X8T
1F2H
1F3V
5XME
6AC0
7CSQ
Enriched GO Terms of Interacting Partners
?
Neurotrophin Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Nerve Growth Factor Signaling Pathway
Regulation Of Apoptotic Process
Response To Growth Factor
Signal Transduction
Response To Nerve Growth Factor
Regulation Of Protein Metabolic Process
Protein-containing Complex
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Protein Modification Process
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of MAPK Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Intracellular Signal Transduction
Enzyme Binding
Apoptotic Process
Regulation Of Multicellular Organismal Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Programmed Cell Death
Cell Death
Identical Protein Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of MAPK Cascade
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Receptor Activity
Neurotrophin Binding
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Growth Factor Stimulus
Signaling Adaptor Activity
Regulation Of Gene Expression
Regulation Of Cellular Component Organization
Circadian Rhythm
Regulation Of Macromolecule Biosynthetic Process
Caveolin-mediated Endocytosis
Nerve Growth Factor Receptor Binding
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Cytokine-mediated Signaling Pathway
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Myelination
Apoptotic Signaling Pathway
Axon Ensheathment
Regulation Of Cell Projection Organization
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Programmed Cell Death
Response To Radiation
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Cell Death
Programmed Cell Death
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Canonical NF-kappaB Signal Transduction
Cytokine-mediated Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Tumor Necrosis Factor Receptor Binding
Cellular Response To Mechanical Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Signaling Adaptor Activity
Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Death Receptor Activity
Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Death-inducing Signaling Complex
Tumor Necrosis Factor Binding
Negative Regulation Of Apoptotic Process
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Lymphocyte Apoptotic Process
Necroptotic Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Thioesterase Binding
CD40 Receptor Complex
Neuron Apoptotic Process
Leukocyte Apoptotic Process
Regulation Of Cell Communication
Regulation Of Signaling
Signaling Receptor Activity
Negative Regulation Of Necroptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Programmed Necrotic Cell Death
Negative Regulation Of Programmed Necrotic Cell Death
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Tagcloud (Intersection)
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