NGFR and KIDINS220

Number of citations of the paper that reports this interaction (PubMedID 11150334)
52

Data Source:
HPRD (two hybrid, in vivo)

		NGFR	KIDINS220
Description		nerve growth factor receptor	kinase D interacting substrate 220
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse	Endosome Late Endosome Cytosol Membrane Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	Protein Binding Protein Kinase Regulator Activity PDZ Domain Binding
	Biological Process	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway	In Utero Embryonic Development Nervous System Development Positive Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	ARMS-mediated activation ARMS-mediated activation RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Alcoholic chronic pancreatitis ( 28754779) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32109663) Neutrophil count ( 21507922) Skin aging measurement ( 31522824) Waist-hip ratio ( 28552196)
Interacting Genes		50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	12 interacting genes: CDC73 CRKL FHL3 KRT34 MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1 SEPTIN5
Entrez ID		4804	57498
HPRD ID		01197	17235
Ensembl ID		ENSG00000064300	ENSG00000134313
Uniprot IDs		P08138	A0A8I5QJC0 Q9ULH0
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation	Neurotrophin Binding Neurotrophin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Circadian Rhythm Cellular Developmental Process Positive Regulation Of Neuron Projection Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Signal Transduction Response To Nerve Growth Factor Nerve Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Neuron Projection Development GPI-linked Ephrin Receptor Activity Positive Regulation Of Synapse Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Postsynaptic Specialization Assembly Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Action Potential Propagation Neuronal Action Potential Propagation Cell Death Programmed Cell Death Rhythmic Process B Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Nervous System Development System Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Positive Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization
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