NGFR and RPN2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NGFR	RPN2
Gene Name		nerve growth factor receptor	ribophorin II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density	Autophagic Vacuole Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Ribosome Binding
	Biological Process	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus	Translation Cellular Protein Modification Process SRP-dependent Cotranslational Protein Targeting To Membrane Aging Gene Expression Protein N-linked Glycosylation Via Asparagine Response To Drug Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling	Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Translation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification SRP-dependent cotranslational protein targeting to membrane Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)	Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274	8 interactors: ADRM1 EZH2 FBN3 NDRG1 NGFR RBBP4 RCHY1 RHOA
Entrez ID		4804	6185
HPRD ID		01197	01609
Ensembl ID		ENSG00000064300	ENSG00000118705
Uniprot IDs		P08138	P04844
PDB IDs		3EWV
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Regulation Of Cell Cycle Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Axonogenesis Regulation Of Epidermis Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Axonogenesis Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Process Positive Regulation Of Cell Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Neurogenesis Regulation Of Proteolysis Negative Regulation Of Cell Projection Organization Regulation Of Neurogenesis Negative Regulation Of Hair Follicle Development Skeletal Muscle Satellite Cell Migration Regulation Of Axonogenesis Negative Regulation Of Cell Differentiation Negative Regulation Of Hair Cycle Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Neuron Differentiation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Gene Expression, Epigenetic Neurotrophin TRK Receptor Signaling Pathway Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Positive Regulation Of Spindle Checkpoint Cleavage Furrow Formation Regulation Of Protein Metabolic Process Central Nervous System Development Nervous System Development G1 To G0 Transition Protein Complex Assembly Cell Cycle Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Cell Cycle Checkpoint Proteasome Assembly Histone H3-K27 Methylation Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	acc1 adp1 aids albicans antiretroviral candida candidiasis decades diploid divergence epidemiology fluconazole gln4 haart heterozygous immunocompromised iran iranian isolate loci mlst multilocus phylogeny polymorphic scheme sya1 typed typing vps13
Tagcloud (Difference) ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	acc1 adp1 aids albicans antiretroviral candida candidiasis decades diploid divergence epidemiology fluconazole gln4 haart heterozygous immunocompromised iran iranian isolate loci mlst multilocus phylogeny polymorphic scheme sya1 typed typing vps13
Tagcloud (Intersection) ?