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H2AFX and NBN
Number of citations of the paper that reports this interaction (PMID
11110662
)
81
Data Source:
HPRD
(in vivo, in vitro)
H2AFX
NBN
Gene Name
H2A histone family, member X
nibrin
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Nuclear Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
PML Body
Mre11 Complex
Site Of Double-strand Break
Nuclear Inclusion Body
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Damaged DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
Transcription Factor Binding
Protein N-terminus Binding
Biological Process
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Blastocyst Growth
DNA Repair
Double-strand Break Repair
Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Mitotic G2 DNA Damage Checkpoint
Cell Proliferation
Regulation Of DNA-dependent DNA Replication Initiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Autophosphorylation
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Isotype Switching
Neuromuscular Process Controlling Balance
Meiotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
ATM mediated phosphorylation of repair proteins
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
MRN complex relocalizes to nuclear foci
ATM mediated response to DNA double-strand break
Cellular Senescence
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
Homologous Recombination Repair
Recruitment of repair and signaling proteins to double-strand breaks
Homologous recombination repair of replication-independent double-strand breaks
Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
27 interactors:
ATF2
ATM
ATR
BRCA1
CCNE1
CDK9
CHEK2
DCLRE1C
EP300
FANCD2
H2AFX
MDC1
MRE11A
NCL
PRKDC
RAD18
RAD50
RECQL5
RNF8
SIRT1
TERF1
TLK1
TREX1
UBE2D1
UBE2N
XRCC4
XRCC5
Entrez ID
3014
4683
HPRD ID
03465
04050
Ensembl ID
ENSG00000188486
ENSG00000104320
Uniprot IDs
P16104
O60934
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
DNA Repair
Cellular Response To Stress
DNA Metabolic Process
Double-strand Break Repair
DNA Recombination
Response To Ionizing Radiation
Response To Stress
Cell Cycle Process
Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Nucleobase-containing Compound Metabolic Process
Response To Radiation
Cell Cycle Checkpoint
Chromosome Organization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To Abiotic Stimulus
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Damage Checkpoint
DNA Replication
Telomere Maintenance
Positive Regulation Of Response To DNA Damage Stimulus
Regulation Of Response To DNA Damage Stimulus
Cellular Response To Stimulus
Mitotic Cell Cycle Process
Regulation Of Cell Cycle
Mitotic Cell Cycle Checkpoint
Mitotic Cell Cycle
Organelle Organization
Response To Stimulus
Response To Gamma Radiation
Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Cell Cycle
Regulation Of Chromosome Organization
Regulation Of DNA Repair
Negative Regulation Of Mitotic Cell Cycle
Intra-S DNA Damage Checkpoint
Regulation Of Mitotic Cell Cycle
Positive Regulation Of DNA Repair
Negative Regulation Of Cellular Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Negative Regulation Of DNA Metabolic Process
Mitotic DNA Integrity Checkpoint
Negative Regulation Of DNA Replication
Regulation Of Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Tagcloud
?
5yrs
atm
atr
brfr
category
cohorts
ddr
decisions
fail
gains
gleason
guided
igrt
mre11a
nibrin
pca
precision
predictor
predicts
prkdc
prostatectomy
psa
rad50
radioresistance
radiotherapy
radp
sensing
sensors
wald
Tagcloud (Difference)
?
5yrs
atm
atr
brfr
category
cohorts
ddr
decisions
fail
gains
gleason
guided
igrt
mre11a
nibrin
pca
precision
predictor
predicts
prkdc
prostatectomy
psa
rad50
radioresistance
radiotherapy
radp
sensing
sensors
wald
Tagcloud (Intersection)
?