NGFR and LINGO1

Number of citations of the paper that reports this interaction (PMID 14966521)
127

Data Source:
HPRD (in vivo, in vitro)

		NGFR	LINGO1
Gene Name		nerve growth factor receptor	leucine rich repeat and Ig domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding	Epidermal Growth Factor Receptor Binding
	Biological Process	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus	Central Nervous System Neuron Development Neuron Projection Development Protein Kinase B Signaling Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis
Pathways		Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling	Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)	Essential tremor ( 19182806)
Protein-Protein Interactions		45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274	8 interactors: EFEMP2 FBXW7 GOLGA2 KRTAP4-12 NGFR RTN4R SPAG5 TRIM27
Entrez ID		4804	84894
HPRD ID		01197	14322
Ensembl ID		ENSG00000064300	ENSG00000169783
Uniprot IDs		P08138	Q96FE5
PDB IDs		3EWV	2ID5
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Negative Regulation Of Axonogenesis Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Projection Development Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Cell Projection Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hair Follicle Development Regulation Of Axonogenesis Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization Regulation Of Organ Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Calcium Ion Import Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Chromosome Segregation Positive Regulation Of Oxidative Stress-induced Cell Death Interferon-gamma Secretion Regulation Of DNA Endoreduplication Negative Regulation Of Neurogenesis Regulation Of Hepatocyte Proliferation Positive Regulation Of Odontogenesis Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Development Negative Regulation Of Viral Release From Host Cell Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Neuron Projection Development Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development Cell Cycle Regulation Of Triglyceride Biosynthetic Process Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Transcription Regulation Of Hair Cycle Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Negative Regulation Of Cell Cycle
Tagcloud ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Difference) ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Intersection) ?