NGFR and NTF4

Number of citations: 0 (PubMedID 7541633)
Data Source: HPRD (in vivo)

		NGFR	NTF4
Name		nerve growth factor receptor	neurotrophin 4
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Long-term Memory Sensory Organ Boundary Specification Adult Locomotory Behavior Epidermis Development Nerve Development Ameloblast Differentiation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Innervation Taste Bud Development
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3
Diseases		None	Primary open angle glaucoma
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502 ) Lower body strength ( 27325353 ) Mean spheric corpuscular volume ( 32888494 ) Prostate cancer ( 23535732 )	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598 )
Interacting Genes		50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	8 interacting genes: ADAMTSL4 BDNF CLIC1 CRX GLRX3 LRP1 NGFR NTRK2
Entrez ID		4804	4909
HPRD ID		01197	01220
Ensembl ID		ENSG00000064300	ENSG00000225950
Uniprot IDs		P08138	P34130
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T	1B8M 1B98 1HCF
GO Terms Enriched among Interactors		Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation	Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Binding Neurotrophin Signaling Pathway Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Synapse Assembly Nerve Development Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Cellular Response To Amyloid-beta Response To Amyloid-beta Apolipoprotein Receptor Activity Brain-derived Neurotrophic Factor Receptor Activity Pigment Cell Development Positive Regulation Of Axonogenesis Retina Development In Camera-type Eye Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Reverse Cholesterol Transport Amyloid-beta Binding Regulation Of Transcytosis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Dendrite Positive Regulation Of Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Lipoprotein Particle Receptor Binding Death Receptor Activity Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Brain-derived Neurotrophic Factor Binding Protease Binding Circadian Rhythm Regulation Of Axonogenesis Positive Regulation Of Developmental Process Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Neurotrophin Receptor Activity Trans-synaptic Signaling By BDNF Dendritic Spine Positive Regulation Of Neuron Projection Development Nerve Growth Factor Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Hair Follicle Development Nerve Growth Factor Binding Regulation Of Synapse Assembly Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death