NGFR and NTF4

Number of citations of the paper that reports this interaction (PMID 7541633)
15

Data Source:
HPRD (in vivo)

		NGFR	NTF4
Gene Name		nerve growth factor receptor	neurotrophin 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density	Extracellular Region Endoplasmic Reticulum Lumen Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding	Neurotrophin P75 Receptor Binding Growth Factor Activity
	Biological Process	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Ganglion Mother Cell Fate Determination Long-term Memory Sensory Organ Boundary Specification Adult Locomotory Behavior Epidermis Development Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Innervation Taste Bud Development
Pathways		Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)
Protein-Protein Interactions		45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274	4 interactors: ADAMTSL4 CLIC1 NGFR NTRK2
Entrez ID		4804	4909
HPRD ID		01197	01220
Ensembl ID		ENSG00000064300	ENSG00000225950
Uniprot IDs		P08138	P34130
PDB IDs		3EWV	1B8M 1B98 1HCF
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Positive Regulation Of Axonogenesis Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Circadian Rhythm Negative Regulation Of Hair Follicle Development Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Neurotrophin Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Projection Organization Regulation Of Apoptotic Process Rhythmic Process Regulation Of Cell Death Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Positive Regulation Of Neurogenesis Protein O-linked Fucosylation Positive Regulation Of Odontogenesis Retinal Rod Cell Development Peripheral Nervous System Neuron Development Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Negative Regulation Of Anoikis Positive Regulation Of Cell Development Regulation Of Odontogenesis Of Dentin-containing Tooth Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development Regulation Of Anoikis Regulation Of Neuron Differentiation Response To Auditory Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Hair Cycle Regulation Of Rac GTPase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cell Death Glutamate Secretion Cellular Response To Nerve Growth Factor Stimulus Anion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Detection Of Temperature Stimulus
Tagcloud ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	actin contain cytosolic exclusively filament fractionation germination kim map mature motif mutagenesis ntmek2 ntprof2 p45 pellet phosphorylate pollen predominantly profilin profilins residue sipk speed substrates thought threonine tobacco tube
Tagcloud (Difference) ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	actin contain cytosolic exclusively filament fractionation germination kim map mature motif mutagenesis ntmek2 ntprof2 p45 pellet phosphorylate pollen predominantly profilin profilins residue sipk speed substrates thought threonine tobacco tube
Tagcloud (Intersection) ?