VAV1 and PIK3R1

Number of citations of the paper that reports this interaction (PMID 9162069)
8

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		VAV1	PIK3R1
Gene Name		vav 1 guanine nucleotide exchange factor	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Transcription Factor Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulator Activity ErbB-3 Class Receptor Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding
	Biological Process	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway	Cellular Glucose Homeostasis Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Phosphatidylinositol 3-kinase Signaling Viral Process Platelet Activation B Cell Differentiation Positive Regulation Of Cell Migration T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Cellular Response To UV Response To Endoplasmic Reticulum Stress Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Phosphatidylinositol Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization T Cell Receptor Signaling Pathway Leukocyte Migration NFAT Protein Import Into Nucleus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway Rho GTPase cycle PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Regulation of signaling by CBL G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by FGFR NRAGE signals death through JNK GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF GP1b-IX-V activation signalling Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade
Drugs			Isoproterenol (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
Diseases
GWAS		Periodontitis ( 23459936)	Alzheimer's disease biomarkers ( 23419831) Menarche (age at onset) ( 23599027)
Protein-Protein Interactions		77 interactors: ABL1 ACTA1 AOC3 ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 EZH2 FGFR1 FYN GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 LMNA MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX	149 interactors: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGFR EPHA2 EPOR ERAS ERBB2 ERBB3 ESR1 EZR FASLG FCGR2A FES FGFR1 FYN GAB1 GAB2 GAB3 GHR GRB2 GSK3B GSPT1 GTF2H1 HCK HCST HDAC1 HGS HOXA1 HRAS HTT IFNAR1 IGF1R IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KHDRBS1 KIT LAT LCK LCP2 MAPK8 MET MME MST1R NFKBIA NTRK1 NTRK2 NUP85 PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PSEN1 PSMB5 PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SRC SSTR2 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TOM1L1 TRAT1 TSHR TTR TUB TUBA1B TUBG1 TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG
Entrez ID		7409	5295
HPRD ID		01284	01381
Ensembl ID		ENSG00000141968	ENSG00000145675
Uniprot IDs		B2R8B5 P15498 Q96D37	P27986
PDB IDs		2CRH 2LCT 2MC1 2ROR 3BJI 3KY9	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Immune System Process Immune Response Cellular Response To Stimulus Regulation Of Immune Response Positive Regulation Of Signal Transduction Defense Response Cell Surface Receptor Signaling Pathway Response To Stimulus Fc-epsilon Receptor Signaling Pathway Signal Transduction Response To Wounding Peptidyl-tyrosine Phosphorylation Response To Organic Substance Cell Activation Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Cell Differentiation Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Neurotrophin TRK Receptor Signaling Pathway Blood Coagulation Neurotrophin Signaling Pathway Hemostasis Antigen Receptor-mediated Signaling Pathway Locomotion System Development Cellular Response To Growth Factor Stimulus Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Body Fluid Levels Platelet Activation Response To Growth Factor Protein Autophosphorylation Developmental Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cellular Response To Stimulus Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Signal Transduction Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Signaling Intracellular Signal Transduction Response To Stimulus Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response Fc Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Kinase Activity Locomotion Defense Response Positive Regulation Of Phosphorylation Response To Growth Factor Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Cell Migration Positive Regulation Of Metabolic Process Cell Activation Phosphatidylinositol-mediated Signaling Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Proliferation Cell Motility
Tagcloud ?		abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer	16q 1q affymetrix classic clustering clusters cytoskeleton distinguished epithelium fresh frozen golm1 gpr137b hierarchical ilc lcis lobular mastectomy microarrays microdissected obligate personalize precursor prophylactic supervised transcriptomic triplets u133a unsupervised
Tagcloud (Difference) ?		abilities abnormally blocking colony csf1 effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer	16q 1q affymetrix classic clustering clusters distinguished epithelium fresh frozen golm1 gpr137b hierarchical ilc lcis lobular mastectomy microarrays microdissected obligate personalize precursor prophylactic supervised transcriptomic triplets u133a unsupervised
Tagcloud (Intersection) ?		cytoskeleton