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VAV1 and LAT
Number of citations of the paper that reports this interaction (PubMedID
11368773
)
33
Data Source:
HPRD
(in vitro, in vivo)
VAV1
LAT
Description
vav guanine nucleotide exchange factor 1
linker for activation of T cells
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Immunological Synapse
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Membrane
TCR Signalosome
Membrane Raft
Molecular Function
Phosphotyrosine Residue Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Phosphorylation-dependent Protein Binding
Protein Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
Signaling Adaptor Activity
Molecular Condensate Scaffold Activity
Biological Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phagocytosis
Immune Response
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Small GTPase-mediated Signal Transduction
Regulation Of Cell Size
Response To Xenobiotic Stimulus
Cell Migration
Natural Killer Cell Activation
Platelet Activation
T Cell Differentiation
Neutrophil Chemotaxis
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
T Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Xenobiotic Stimulus
Reactive Oxygen Species Metabolic Process
Adaptive Immune Response
Lymphocyte Homeostasis
Immune System Process
Inflammatory Response
Immune Response
Signal Transduction
Integrin-mediated Signaling Pathway
Ras Protein Signal Transduction
Gene Expression
Calcium-mediated Signaling
Membrane Raft Distribution
Intracellular Signal Transduction
T Cell Activation
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Kinase Activity
Homeostasis Of Number Of Cells
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CD28 dependent Vav1 pathway
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
VEGFR2 mediated vascular permeability
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOA GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Azathioprine ADME
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
GPVI-mediated activation cascade
Generation of second messenger molecules
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Lymphocyte count (
32888494
)
Mean platelet volume (
27863252
32888494
)
Periodontitis (
23459936
)
Platelet count (
32888494
)
Platelet distribution width (
27863252
32888494
)
Allergic disease (asthma, hay fever or eczema) (
29679657
)
Crohn's disease (
21102463
)
Educational attainment (
25201988
)
Interacting Genes
80 interacting genes:
ABL1
ACTA1
AOC3
AR
ARHGDIA
ARHGDIB
BCR
BLNK
BTK
CASP3
CBL
CBLB
CD19
CDC42
CFTR
CRK
CXCR4
DNM2
DOCK2
DOK1
EGFR
EMD
EPOR
ERBB2
ERBB3
ERBB4
EZH2
FGFR1
FYN
GAB1
GRB2
HCK
HNRNPK
HRAS
IL6ST
INSR
JAK2
JUN
KHDRBS1
LAT
LCK
LCP2
MAPK1
MERTK
MET
NEK3
PAG1
PDGFRB
PHAX
PIK3R1
PLCG1
PRKCQ
PRLR
PTK2B
PTPN22
PTPN6
RAC1
RACGAP1
RAF1
RHOA
RHOG
S100B
SH3BP2
SHB
SHC1
SIAH1
SIAH2
SLA
SOCS1
SYK
TEC
TUBA1A
TUBA4A
TUBB
TYK2
XRCC5
XRCC6
ZAP70
ZNF655
ZYX
96 interacting genes:
APH1A
ASGR2
BCL2L13
BSCL2
CAMLG
CBL
CD244
CD3G
CD4
CD53
CD8A
CDIP1
CLDN2
CLDN5
CLDN7
CREB3
CXorf66
CYBC1
EGFR
FAM209A
FCGR1A
FCGR2A
FFAR2
FFAR3
FKBP7
FYN
GAB2
GJA8
GJB1
GJB3
GOLM1
GPR101
GPR151
GPR152
GPR42
GRAP
GRAP2
GRB2
ITK
JSRP1
KASH5
KCTD17
KIR2DL3
LCK
LCP2
LEUTX
LHFPL1
LHFPL5
LMNA
MAP1LC3C
MAP4K1
MEOX2
MFF
MRPS18B
MS4A7
MTIF3
NDUFAF2
OPRM1
PIK3R1
PLCG1
PLCG2
PRR4
PSCA
PTPN1
PTPN6
PTPRJ
SAR1A
SERINC2
SGTA
SGTB
SH3BP2
SHB
SLA
SLC14A2
SLC16A2
SLC18A1
SLC19A3
SLC26A6
SLC35H1
SLC51B
SLC61A1
SLC71A2
SLPI
SSMEM1
SYK
SYT2
THAP4
TM4SF18
TMEM237
TMEM45B
TMEM80
TNFRSF10D
VAV1
ZAP70
ZDHHC7
ZHX2
Entrez ID
7409
27040
HPRD ID
01284
03832
Ensembl ID
ENSG00000141968
ENSG00000213658
Uniprot IDs
A0A0A0MR07
B2R8B5
P15498
Q96D37
O43561
PDB IDs
2CRH
2LCT
2MC1
2ROR
3BJI
3KY9
6NEW
6NF1
6NFA
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Antigen Receptor-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Lymphocyte Activation
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Cellular Developmental Process
Regulation Of Cell Activation
Intracellular Signaling Cassette
Activation Of Immune Response
Regulation Of Cell Population Proliferation
Positive Regulation Of Immune Response
Cell Differentiation
Protein Phosphorylation
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune Response
Phosphorylation
Leukocyte Activation
Protein Kinase Activity
Regulation Of T Cell Activation
Lymphocyte Activation
Regulation Of Programmed Cell Death
Developmental Process
Positive Regulation Of Protein Phosphorylation
Nucleotide Binding
Regulation Of Apoptotic Process
Phosphotyrosine Residue Binding
Membrane
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Plasma Membrane
Immune Response-activating Signaling Pathway
Cell-cell Junction
Activation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Immune Response
Positive Regulation Of Immune Response
Fc Receptor Signaling Pathway
Lymphocyte Activation
Leukocyte Activation
Immune System Process
Regulation Of Immune System Process
Immune Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Binding
Signal Transduction
Fc-gamma Receptor Signaling Pathway
Cell Activation
T Cell Activation
Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Immune Effector Process
B Cell Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Lymphocyte Differentiation
T Cell Differentiation
Positive Regulation Of Immune Effector Process
Membrane Raft
T Cell Receptor Complex
Neurotrophin TRKA Receptor Binding
Gamma-delta T Cell Activation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Leukocyte Mediated Cytotoxicity
Regulation Of Transport
Lymphocyte Mediated Immunity
T Cell Costimulation
Adaptive Immune Response
Leukocyte Differentiation
Peptidyl-tyrosine Phosphorylation
Fc-epsilon Receptor Signaling Pathway
Identical Protein Binding
Positive Regulation Of Transport
Mononuclear Cell Differentiation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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