VAV1 and MERTK

Number of citations of the paper that reports this interaction (PMID 12920122)
26

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		VAV1	MERTK
Gene Name		vav 1 guanine nucleotide exchange factor	MER proto-oncogene, tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway	Natural Killer Cell Differentiation Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Blood Coagulation Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Protein Kinase B Signaling Positive Regulation Of Phagocytosis Leukocyte Migration Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway Rho GTPase cycle PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Regulation of signaling by CBL G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by FGFR NRAGE signals death through JNK GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Periodontitis ( 23459936)	Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		77 interactors: ABL1 ACTA1 AOC3 ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 EZH2 FGFR1 FYN GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 LMNA MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX	8 interactors: BMPR2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1
Entrez ID		7409	10461
HPRD ID		01284	05269
Ensembl ID		ENSG00000141968	ENSG00000153208
Uniprot IDs		B2R8B5 P15498 Q96D37	E9PHX8 Q12866
PDB IDs		2CRH 2LCT 2MC1 2ROR 3BJI 3KY9	2DBJ 2P0C 3BPR 3BRB 3TCP
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Immune System Process Immune Response Cellular Response To Stimulus Regulation Of Immune Response Positive Regulation Of Signal Transduction Defense Response Cell Surface Receptor Signaling Pathway Response To Stimulus Fc-epsilon Receptor Signaling Pathway Signal Transduction Response To Wounding Peptidyl-tyrosine Phosphorylation Response To Organic Substance Cell Activation Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Cell Differentiation Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Neurotrophin TRK Receptor Signaling Pathway Blood Coagulation Neurotrophin Signaling Pathway Hemostasis Antigen Receptor-mediated Signaling Pathway Locomotion System Development Cellular Response To Growth Factor Stimulus Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Body Fluid Levels Platelet Activation Response To Growth Factor Protein Autophosphorylation Developmental Process	Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cellular Component Organization Response To Stress Regulation Of Cell Activation Immune System Process Positive Regulation Of Protein Metabolic Process Viral Process Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Cellular Response To Growth Factor Stimulus Immune Response Regulation Of Phosphorylation Regulation Of Endocytosis Response To Growth Factor Platelet Activation Endocytosis Positive Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Phagocytosis Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Metabolic Process Positive Regulation Of Cell Activation Positive Regulation Of Phosphorylation Regulation Of Signaling Negative Regulation Of Blood Pressure Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Response To External Stimulus Positive Regulation Of Immune System Process Cell Motility Positive Regulation Of Protein Modification Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Lymphocyte Activation Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Signaling
Tagcloud ?		abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer	apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2
Tagcloud (Difference) ?		abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer	apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2
Tagcloud (Intersection) ?