VAV1 and NEK3

Number of citations of the paper that reports this interaction (PubMedID 15618286)
0

Data Source:
HPRD (in vivo)

		VAV1	NEK3
Description		vav guanine nucleotide exchange factor 1	NIMA related kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction	Nucleus Cytoplasm Axon Cell Projection
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Phosphorylation-dependent Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis Immune Response G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Natural Killer Cell Activation Platelet Activation T Cell Differentiation Neutrophil Chemotaxis T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus Reactive Oxygen Species Metabolic Process	Mitotic Cell Cycle Protein Phosphorylation Cell Division
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Potential therapeutics for SARS Azathioprine ADME Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Lymphocyte count ( 32888494) Mean platelet volume ( 27863252 32888494) Periodontitis ( 23459936) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		80 interacting genes: ABL1 ACTA1 AOC3 AR ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CFTR CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 ERBB4 EZH2 FGFR1 FYN GAB1 GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX	6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2
Entrez ID		7409	4752
HPRD ID		01284	04954
Ensembl ID		ENSG00000141968	ENSG00000136098
Uniprot IDs		A0A0A0MR07 B2R8B5 P15498 Q96D37	P51956 Q6ZN64
PDB IDs		2CRH 2LCT 2MC1 2ROR 3BJI 3KY9 6NEW 6NF1 6NFA
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Cellular Developmental Process Regulation Of Cell Activation Intracellular Signaling Cassette Activation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Cell Differentiation Protein Phosphorylation Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Adhesion Regulation Of Immune Response Phosphorylation Leukocyte Activation Protein Kinase Activity Regulation Of T Cell Activation Lymphocyte Activation Regulation Of Programmed Cell Death Developmental Process Positive Regulation Of Protein Phosphorylation Nucleotide Binding Regulation Of Apoptotic Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Phosphotyrosine Residue Binding Fc Receptor Signaling Pathway Cellular Response To Xenobiotic Stimulus Platelet Activation Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Size Phosphoglycerate Mutase Activity Nicotinamide Nucleotide Metabolic Process Bisphosphoglycerate Mutase Activity Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Receptor Activity Positive Regulation Of Signal Transduction Nicotinate-nucleotide Adenylyltransferase Activity Negative Regulation Of Apoptotic DNA Fragmentation Nicotinamide-nucleotide Adenylyltransferase Activity ATP Metabolic Process Prolactin Signaling Pathway Activation Of Janus Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein ADP-ribosyltransferase-substrate Adaptor Activity ATP Generation From Poly-ADP-D-ribose Nicotinamide Metabolic Process Chromosome Passenger Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Guanyl-nucleotide Exchange Factor Activity Purine Ribonucleotide Metabolic Process Intramolecular Phosphotransferase Activity Establishment Of Blood-brain Barrier Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Positive Regulation Of Immune System Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Mammary Gland Epithelium Development Prostate Gland Growth Response To Xenobiotic Stimulus Regulation Of Cellular Component Size Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase-mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Positive Regulation Of Mitotic Cytokinesis
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