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VAV1 and RHOG
Number of citations of the paper that reports this interaction (PubMedID
12376551
)
0
Data Source:
HPRD
(in vitro)
VAV1
RHOG
Description
vav guanine nucleotide exchange factor 1
ras homolog family member G
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Membrane
Secretory Granule Membrane
Cytoplasmic Vesicle
Cell Projection
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Molecular Function
Phosphotyrosine Residue Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Phosphorylation-dependent Protein Binding
Nucleotide Binding
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Binding
Biological Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phagocytosis
Immune Response
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Small GTPase-mediated Signal Transduction
Regulation Of Cell Size
Response To Xenobiotic Stimulus
Cell Migration
Natural Killer Cell Activation
Platelet Activation
T Cell Differentiation
Neutrophil Chemotaxis
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
T Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Xenobiotic Stimulus
Reactive Oxygen Species Metabolic Process
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Small GTPase-mediated Signal Transduction
Rho Protein Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Rac Protein Signal Transduction
Actin Cytoskeleton Organization
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of DNA-templated Transcription
Cell Chemotaxis
Activation Of GTPase Activity
Regulation Of Postsynapse Assembly
Regulation Of Ruffle Assembly
Positive Regulation Of Protein Localization To Plasma Membrane
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CD28 dependent Vav1 pathway
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
VEGFR2 mediated vascular permeability
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOA GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Azathioprine ADME
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RHO GTPases activate KTN1
Neutrophil degranulation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOG GTPase cycle
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Lymphocyte count (
32888494
)
Mean platelet volume (
27863252
32888494
)
Periodontitis (
23459936
)
Platelet count (
32888494
)
Platelet distribution width (
27863252
32888494
)
Eosinophilic esophagitis (
34506852
)
Lymphocyte percentage of white cells (
32888494
)
Malaria (
31844061
)
Plateletcrit (
32888494
)
Interacting Genes
80 interacting genes:
ABL1
ACTA1
AOC3
AR
ARHGDIA
ARHGDIB
BCR
BLNK
BTK
CASP3
CBL
CBLB
CD19
CDC42
CFTR
CRK
CXCR4
DNM2
DOCK2
DOK1
EGFR
EMD
EPOR
ERBB2
ERBB3
ERBB4
EZH2
FGFR1
FYN
GAB1
GRB2
HCK
HNRNPK
HRAS
IL6ST
INSR
JAK2
JUN
KHDRBS1
LAT
LCK
LCP2
MAPK1
MERTK
MET
NEK3
PAG1
PDGFRB
PHAX
PIK3R1
PLCG1
PRKCQ
PRLR
PTK2B
PTPN22
PTPN6
RAC1
RACGAP1
RAF1
RHOA
RHOG
S100B
SH3BP2
SHB
SHC1
SIAH1
SIAH2
SLA
SOCS1
SYK
TEC
TUBA1A
TUBA4A
TUBB
TYK2
XRCC5
XRCC6
ZAP70
ZNF655
ZYX
24 interacting genes:
ARHGDIA
ARHGDIG
CCR2
CEBPA
DOCK1
ECT2
ELMO1
ELMO2
ELMOD2
ERCC6
IQGAP2
KTN1
MAP3K11
MCF2
MCF2L
PLD1
RSPH1
SMAD1
SMAD4
TGFBR1
UBC
VAV1
VAV2
VAV3
Entrez ID
7409
391
HPRD ID
01284
01537
Ensembl ID
ENSG00000141968
ENSG00000177105
Uniprot IDs
A0A0A0MR07
B2R8B5
P15498
Q96D37
P84095
Q6ICQ8
PDB IDs
2CRH
2LCT
2MC1
2ROR
3BJI
3KY9
6NEW
6NF1
6NFA
6UKA
7Y4A
8XM7
8ZJ2
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Antigen Receptor-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Lymphocyte Activation
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Cellular Developmental Process
Regulation Of Cell Activation
Intracellular Signaling Cassette
Activation Of Immune Response
Regulation Of Cell Population Proliferation
Positive Regulation Of Immune Response
Cell Differentiation
Protein Phosphorylation
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune Response
Phosphorylation
Leukocyte Activation
Protein Kinase Activity
Regulation Of T Cell Activation
Lymphocyte Activation
Regulation Of Programmed Cell Death
Developmental Process
Positive Regulation Of Protein Phosphorylation
Nucleotide Binding
Regulation Of Apoptotic Process
Intracellular Signal Transduction
Intracellular Signaling Cassette
Guanyl-nucleotide Exchange Factor Activity
Small GTPase-mediated Signal Transduction
Signal Transduction
GTPase Activator Activity
Regulation Of Small GTPase Mediated Signal Transduction
Phagocytosis
I-SMAD Binding
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-epsilon Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Rho GDP-dissociation Inhibitor Activity
Cell Motility
Fc-gamma Receptor Signaling Pathway
Cell Migration
Guanyl-nucleotide Exchange Factor Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Fc Receptor Signaling Pathway
Cytosol
Positive Regulation Of Extracellular Matrix Assembly
Endothelial Cell Activation
Chemotaxis
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Intracellular Signal Transduction
Locomotion
Platelet Activation
Cytoplasm
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Cell Chemotaxis
Regulation Of Cell Size
Regulation Of Synaptic Vesicle Cycle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Interleukin-6-mediated Signaling Pathway
Cardiac Conduction System Development
MAPK Cascade
Endocytosis
Integrin-mediated Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Extracellular Matrix Assembly
SH3 Domain Binding
SMAD Protein Signal Transduction
Small GTPase Binding
Positive Regulation Of Extracellular Matrix Organization
Response To Xenobiotic Stimulus
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Tagcloud (Difference)
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Tagcloud (Intersection)
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