Wiki-Pi
About
Search
People
Updates
Search
VAV1 and TUBA4A
Number of citations of the paper that reports this interaction (PubMedID
8530437
)
0
Data Source:
HPRD
(in vivo, in vitro)
VAV1
TUBA4A
Description
vav guanine nucleotide exchange factor 1
tubulin alpha 4a
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Extracellular Region
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Cilium
Microtubule Cytoskeleton
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Phosphorylation-dependent Protein Binding
Nucleotide Binding
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Hydrolase Activity
Enzyme Binding
Protein Kinase Binding
Metal Ion Binding
Biological Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phagocytosis
Immune Response
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Small GTPase-mediated Signal Transduction
Regulation Of Cell Size
Response To Xenobiotic Stimulus
Cell Migration
Natural Killer Cell Activation
Platelet Activation
T Cell Differentiation
Neutrophil Chemotaxis
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
T Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Xenobiotic Stimulus
Reactive Oxygen Species Metabolic Process
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CD28 dependent Vav1 pathway
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
VEGFR2 mediated vascular permeability
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOA GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Azathioprine ADME
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Platelet degranulation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Cargo trafficking to the periciliary membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
PKR-mediated signaling
Drugs
Vincristine
Podofilox
Epothilone D
Patupilone
CYT997
Cabazitaxel
Phenethyl Isothiocyanate
Diseases
GWAS
Blood protein levels (
30072576
)
Lymphocyte count (
32888494
)
Mean platelet volume (
27863252
32888494
)
Periodontitis (
23459936
)
Platelet count (
32888494
)
Platelet distribution width (
27863252
32888494
)
Platelet distribution width (
27863252
32888494
)
Severe autoimmune type 2 diabetes (
34737425
)
Interacting Genes
80 interacting genes:
ABL1
ACTA1
AOC3
AR
ARHGDIA
ARHGDIB
BCR
BLNK
BTK
CASP3
CBL
CBLB
CD19
CDC42
CFTR
CRK
CXCR4
DNM2
DOCK2
DOK1
EGFR
EMD
EPOR
ERBB2
ERBB3
ERBB4
EZH2
FGFR1
FYN
GAB1
GRB2
HCK
HNRNPK
HRAS
IL6ST
INSR
JAK2
JUN
KHDRBS1
LAT
LCK
LCP2
MAPK1
MERTK
MET
NEK3
PAG1
PDGFRB
PHAX
PIK3R1
PLCG1
PRKCQ
PRLR
PTK2B
PTPN22
PTPN6
RAC1
RACGAP1
RAF1
RHOA
RHOG
S100B
SH3BP2
SHB
SHC1
SIAH1
SIAH2
SLA
SOCS1
SYK
TEC
TUBA1A
TUBA4A
TUBB
TYK2
XRCC5
XRCC6
ZAP70
ZNF655
ZYX
53 interacting genes:
APC
ARHGAP1
B4GALT1
BCAR1
BRCA1
C4orf17
CALB2
EGFR
ENO2
EPB41
FYN
GNAI2
GPHN
GRM7
HDAC6
HSPH1
LGALS2
LTA
MAGED1
MAP1A
MAP1LC3A
MAPT
MARK4
MYC
NCALD
OGT
PFDN4
PLK1
PRKN
RAB8B
RAC1
RACGAP1
RBM23
RTN4
S100A8
SIAH1
SIMC1
SIRT2
STARD13
SUMO2
SYK
TAOK2
TBCB
TBCE
TCP1
TCP11L2
TM4SF1
UBC
UCHL5
VAV1
VDAC1
YWHAG
ZAP70
Entrez ID
7409
7277
HPRD ID
01284
01851
Ensembl ID
ENSG00000141968
ENSG00000127824
Uniprot IDs
A0A0A0MR07
B2R8B5
P15498
Q96D37
P68366
PDB IDs
2CRH
2LCT
2MC1
2ROR
3BJI
3KY9
6NEW
6NF1
6NFA
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Antigen Receptor-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Lymphocyte Activation
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Cellular Developmental Process
Regulation Of Cell Activation
Intracellular Signaling Cassette
Activation Of Immune Response
Regulation Of Cell Population Proliferation
Positive Regulation Of Immune Response
Cell Differentiation
Protein Phosphorylation
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune Response
Phosphorylation
Leukocyte Activation
Protein Kinase Activity
Regulation Of T Cell Activation
Lymphocyte Activation
Regulation Of Programmed Cell Death
Developmental Process
Positive Regulation Of Protein Phosphorylation
Nucleotide Binding
Regulation Of Apoptotic Process
Alpha-tubulin Binding
Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Programmed Cell Death
Microtubule
Cytosol
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Apoptotic Process
Ubiquitin Protein Ligase Binding
Regulation Of Cellular Component Organization
Regulation Of Protein Localization
Regulation Of Apoptotic Process
Positive Regulation Of Protein Localization
Plasma Membrane
Tubulin Binding
Regulation Of Protein Catabolic Process
Dendrite
Positive Regulation Of Intracellular Signal Transduction
Cell Migration
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Organelle Organization
Cytoskeleton
Regulation Of Multicellular Organismal Process
Microtubule Binding
Tau Protein Binding
Regulation Of Cytoskeleton Organization
Regulation Of Intracellular Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Signal Transduction
Cell Motility
Negative Regulation Of Catabolic Process
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Plasma Membrane Bounded Cell Projection
Negative Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Cellular Component Organization
Modulation Of Chemical Synaptic Transmission
Leukocyte Migration
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Cellular Response To L-glutamate
Inclusion Body Assembly
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Tubulin Complex Assembly
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?