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VAV1 and CRK
Number of citations of the paper that reports this interaction (PubMedID
8621483
)
0
Data Source:
HPRD
(in vivo)
VAV1
CRK
Description
vav guanine nucleotide exchange factor 1
CRK proto-oncogene, adaptor protein
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Membrane
Neuromuscular Junction
Protein-containing Complex
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Phosphorylation-dependent Protein Binding
Phosphotyrosine Residue Binding
Signaling Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Domain Specific Binding
Signaling Receptor Complex Adaptor Activity
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Binding
Biological Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phagocytosis
Immune Response
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Small GTPase-mediated Signal Transduction
Regulation Of Cell Size
Response To Xenobiotic Stimulus
Cell Migration
Natural Killer Cell Activation
Platelet Activation
T Cell Differentiation
Neutrophil Chemotaxis
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
T Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Xenobiotic Stimulus
Reactive Oxygen Species Metabolic Process
Neuron Migration
Response To Yeast
Regulation Of Leukocyte Migration
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Signal Transduction
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Rac Protein Signal Transduction
Helper T Cell Diapedesis
Response To Hepatocyte Growth Factor
Reelin-mediated Signaling Pathway
Response To Hydrogen Peroxide
Regulation Of GTPase Activity
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of JNK Cascade
Ephrin Receptor Signaling Pathway
Regulation Of Dendrite Development
Cell Chemotaxis
Regulation Of Wound Healing
Negative Regulation Of Wound Healing
Response To Cholecystokinin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Nitric Oxide
Protein Localization To Membrane
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Response To Peptide
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Endothelin
Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Regulation Of T Cell Migration
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CD28 dependent Vav1 pathway
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
VEGFR2 mediated vascular permeability
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOA GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Azathioprine ADME
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
ARMS-mediated activation
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Lymphocyte count (
32888494
)
Mean platelet volume (
27863252
32888494
)
Periodontitis (
23459936
)
Platelet count (
32888494
)
Platelet distribution width (
27863252
32888494
)
Atrial fibrillation (
30061737
)
Granulocyte count (
27863252
)
Intraocular pressure (
30591961
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Pulse pressure (
27841878
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systolic blood pressure (
27841878
28135244
30578418
)
Interacting Genes
80 interacting genes:
ABL1
ACTA1
AOC3
AR
ARHGDIA
ARHGDIB
BCR
BLNK
BTK
CASP3
CBL
CBLB
CD19
CDC42
CFTR
CRK
CXCR4
DNM2
DOCK2
DOK1
EGFR
EMD
EPOR
ERBB2
ERBB3
ERBB4
EZH2
FGFR1
FYN
GAB1
GRB2
HCK
HNRNPK
HRAS
IL6ST
INSR
JAK2
JUN
KHDRBS1
LAT
LCK
LCP2
MAPK1
MERTK
MET
NEK3
PAG1
PDGFRB
PHAX
PIK3R1
PLCG1
PRKCQ
PRLR
PTK2B
PTPN22
PTPN6
RAC1
RACGAP1
RAF1
RHOA
RHOG
S100B
SH3BP2
SHB
SHC1
SIAH1
SIAH2
SLA
SOCS1
SYK
TEC
TUBA1A
TUBA4A
TUBB
TYK2
XRCC5
XRCC6
ZAP70
ZNF655
ZYX
189 interacting genes:
ABL1
ABL2
ADGRL3
ANKZF1
ANLN
AR
ARHGAP17
ARHGAP32
ASAP1
ASAP3
ASCL4
ATF3
ATXN1
AVIL
BATF3
BCAR1
BCR
BEX5
BICRA
BUB1
C1orf94
C4orf17
C6orf141
CBL
CBLC
CHTF18
CLNK
CNDP2
CORO6
CRKL
DAB1
DOCK1
DOCK3
DOCK5
DOK1
DOK2
DOK3
DOK4
DOK7
DPPA4
EFS
EGFR
ELK1
ELK3
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
EPYC
ERBB2
ERBB3
ERBB4
ESD
EYA3
FAM110B
FASLG
FER
FGFR1
FLACC1
FLT1
FRS2
FSTL1
FYN
GAB1
GABPB2
GAREM1
GRB2
HABP4
HSH2D
IFT140
IGF1R
IKZF3
INO80E
INPP5D
INSR
IQCE
IRS1
IRS2
IRS4
ISL1
IVL
KCNJ3
KCTD13
KCTD17
KDR
KHDRBS1
KIT
KLF15
KLHL20
KMT2E
LASP1
LHX8
LNX2
MAGEC3
MAP4K1
MAP4K5
MAPK4
MAPK8
MET
MICAL1
MNDA
MPG
MYLIP
MYOZ2
NCK1
NEDD9
NPM3
NTRK1
NUFIP2
OFCC1
PAFAH1B2
PDGFRA
PDGFRB
PHC2
PIK3R1
PIK3R2
PIK3R3
PLSCR1
POT1
PPFIBP2
PPP1CA
PRKACA
PRR14
PRRC2B
PRRG2
PSMC1
PSMC6
PTK2
PTK2B
PTPN1
PTPN22
PTPN4
PTPRH
PTTG1
PXN
RAB2B
RAD54L2
RAPGEF1
REPS1
RET
RTCB
RYBP
SASH1
SAXO1
SEMA4D
SEPTIN6
SETD9
SH2B1
SH2D2A
SH3BP1
SHB
SHC1
SOCS1
SOCS6
SOS1
SPATA31F1
SPEN
SPRR2A
STAT4
STAT5A
STAT5B
STRN4
SYN1
SYNGAP1
TASOR2
TCAP
TCOF1
TDG
TERF2IP
TM4SF19
TP53BP2
TRIM25
TUBA1C
TWIST2
TXK
USP53
VAC14
VAV1
VPS37B
WASF1
WDR83
WEE1
XPO1
ZAP70
ZKSCAN5
ZKSCAN7
ZNF557
ZNF804A
Entrez ID
7409
1398
HPRD ID
01284
01267
Ensembl ID
ENSG00000141968
ENSG00000167193
Uniprot IDs
A0A0A0MR07
B2R8B5
P15498
Q96D37
A0A0S2Z3K9
A0A0S2Z3Q4
L7RT18
P46108
PDB IDs
2CRH
2LCT
2MC1
2ROR
3BJI
3KY9
6NEW
6NF1
6NFA
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
2MS4
5UL6
6ATV
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Antigen Receptor-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Lymphocyte Activation
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Cellular Developmental Process
Regulation Of Cell Activation
Intracellular Signaling Cassette
Activation Of Immune Response
Regulation Of Cell Population Proliferation
Positive Regulation Of Immune Response
Cell Differentiation
Protein Phosphorylation
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune Response
Phosphorylation
Leukocyte Activation
Protein Kinase Activity
Regulation Of T Cell Activation
Lymphocyte Activation
Regulation Of Programmed Cell Death
Developmental Process
Positive Regulation Of Protein Phosphorylation
Nucleotide Binding
Regulation Of Apoptotic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Cell Migration
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Protein Binding
Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Insulin Receptor Signaling Pathway
Cytosol
Protein Phosphorylation
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
ERBB Signaling Pathway
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Cytoplasm
Protein Autophosphorylation
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Cell Migration
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Cell Motility
Regulation Of Cell Adhesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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