VAV1 and PRKCQ

Number of citations of the paper that reports this interaction (PMID 10725744)
9

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		VAV1	PRKCQ
Gene Name		vav 1 guanine nucleotide exchange factor	protein kinase C, theta
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction	Immunological Synapse Cytosol Plasma Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Inflammatory Response Axon Guidance Blood Coagulation Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Protein Ubiquitination Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway Rho GTPase cycle PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Regulation of signaling by CBL G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by FGFR NRAGE signals death through JNK GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization	G alpha (q) signalling events Signaling by GPCR Downstream TCR signaling Axon guidance Effects of PIP2 hydrolysis FCERI mediated NF-kB activation Inactivation, recovery and regulation of the phototransduction cascade Gastrin-CREB signalling pathway via PKC and MAPK The phototransduction cascade Programmed Cell Death G alpha (z) signalling events Netrin-1 signaling Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase Diseases associated with visual transduction G alpha (q) signalling events GPCR downstream signaling TCR signaling Visual phototransduction Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System
Drugs			Staurosporine Phosphonothreonine Phosphonoserine
Diseases
GWAS		Periodontitis ( 23459936)	Asthma (bronchodilator response) ( 23508266) Body mass index (asthmatics) ( 23517042) Immune response to smallpox vaccine (IL-6) ( 22542470) Rheumatoid arthritis ( 18794853 20453842) Type 1 diabetes ( 19430480 18978792)
Protein-Protein Interactions		77 interactors: ABL1 ACTA1 AOC3 ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 EZH2 FGFR1 FYN GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 LMNA MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX	28 interactors: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN NFE2L2 RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ
Entrez ID		7409	5588
HPRD ID		01284	02710
Ensembl ID		ENSG00000141968	ENSG00000065675
Uniprot IDs		B2R8B5 P15498 Q96D37	Q04759
PDB IDs		2CRH 2LCT 2MC1 2ROR 3BJI 3KY9	1XJD 2ENJ 2ENN 2ENZ 2JED
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Immune System Process Immune Response Cellular Response To Stimulus Regulation Of Immune Response Positive Regulation Of Signal Transduction Defense Response Cell Surface Receptor Signaling Pathway Response To Stimulus Fc-epsilon Receptor Signaling Pathway Signal Transduction Response To Wounding Peptidyl-tyrosine Phosphorylation Response To Organic Substance Cell Activation Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Cell Differentiation Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Neurotrophin TRK Receptor Signaling Pathway Blood Coagulation Neurotrophin Signaling Pathway Hemostasis Antigen Receptor-mediated Signaling Pathway Locomotion System Development Cellular Response To Growth Factor Stimulus Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Body Fluid Levels Platelet Activation Response To Growth Factor Protein Autophosphorylation Developmental Process	Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Immune System Process T Cell Costimulation Regulation Of Cell Death Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor T Cell Receptor Signaling Pathway Signal Transduction Regulation Of Signaling Immune Response Regulation Of Lymphocyte Activation Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Defense Response Lymphocyte Homeostasis Signaling Response To Growth Factor Cell Communication Response To Organic Substance Response To Stress Cellular Response To Stimulus Regulation Of T Cell Activation Leukocyte Homeostasis Phosphorylation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus
Tagcloud ?		abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer	aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 rpa3 softwares vav3 zap70
Tagcloud (Difference) ?		abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer	aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 rpa3 softwares vav3 zap70
Tagcloud (Intersection) ?