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VAV1 and SIAH2
Number of citations of the paper that reports this interaction (PubMedID
10207103
)
73
Data Source:
BioGRID
(two hybrid, pull down, affinity chromatography technology)
HPRD
(two hybrid, in vitro, in vivo)
VAV1
SIAH2
Description
vav guanine nucleotide exchange factor 1
siah E3 ubiquitin protein ligase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Nucleus
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Neuronal Cell Body
Molecular Function
Phosphotyrosine Residue Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Phosphorylation-dependent Protein Binding
Transcription Corepressor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Ubiquitin Conjugating Enzyme Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phagocytosis
Immune Response
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Small GTPase-mediated Signal Transduction
Regulation Of Cell Size
Response To Xenobiotic Stimulus
Cell Migration
Natural Killer Cell Activation
Platelet Activation
T Cell Differentiation
Neutrophil Chemotaxis
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
T Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Xenobiotic Stimulus
Reactive Oxygen Species Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Small GTPase-mediated Signal Transduction
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Rhythmic Process
Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Amyloid Fibril Formation
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
NRAGE signals death through JNK
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CD28 dependent Vav1 pathway
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
VEGFR2 mediated vascular permeability
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOA GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Azathioprine ADME
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Lymphocyte count (
32888494
)
Mean platelet volume (
27863252
32888494
)
Periodontitis (
23459936
)
Platelet count (
32888494
)
Platelet distribution width (
27863252
32888494
)
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
22951594
31757997
)
Interacting Genes
80 interacting genes:
ABL1
ACTA1
AOC3
AR
ARHGDIA
ARHGDIB
BCR
BLNK
BTK
CASP3
CBL
CBLB
CD19
CDC42
CFTR
CRK
CXCR4
DNM2
DOCK2
DOK1
EGFR
EMD
EPOR
ERBB2
ERBB3
ERBB4
EZH2
FGFR1
FYN
GAB1
GRB2
HCK
HNRNPK
HRAS
IL6ST
INSR
JAK2
JUN
KHDRBS1
LAT
LCK
LCP2
MAPK1
MERTK
MET
NEK3
PAG1
PDGFRB
PHAX
PIK3R1
PLCG1
PRKCQ
PRLR
PTK2B
PTPN22
PTPN6
RAC1
RACGAP1
RAF1
RHOA
RHOG
S100B
SH3BP2
SHB
SHC1
SIAH1
SIAH2
SLA
SOCS1
SYK
TEC
TUBA1A
TUBA4A
TUBB
TYK2
XRCC5
XRCC6
ZAP70
ZNF655
ZYX
46 interacting genes:
AFF1
AKR1C3
ATN1
CACYBP
CCAR2
CCBE1
CHEK2
DCC
DLST
DYRK2
EEF1D
EGLN3
HIPK2
HIPK3
LATS2
MYD88
NRF1
OPRM1
PEG10
PEG3
PIAS2
PIAS3
PML
POU2AF1
PSMD4
RBBP8
SETD2
SNCA
SNCAIP
SPRY2
STAT3
SYP
TINF2
TP53BP2
TPX2
TRAF2
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2L6
UBE2N
UBE2V2
USP13
USP19
VAV1
Entrez ID
7409
6478
HPRD ID
01284
03737
Ensembl ID
ENSG00000141968
ENSG00000181788
Uniprot IDs
A0A0A0MR07
B2R8B5
P15498
Q96D37
O43255
PDB IDs
2CRH
2LCT
2MC1
2ROR
3BJI
3KY9
6NEW
6NF1
6NFA
5H9M
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Antigen Receptor-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Lymphocyte Activation
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Cellular Developmental Process
Regulation Of Cell Activation
Intracellular Signaling Cassette
Activation Of Immune Response
Regulation Of Cell Population Proliferation
Positive Regulation Of Immune Response
Cell Differentiation
Protein Phosphorylation
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune Response
Phosphorylation
Leukocyte Activation
Protein Kinase Activity
Regulation Of T Cell Activation
Lymphocyte Activation
Regulation Of Programmed Cell Death
Developmental Process
Positive Regulation Of Protein Phosphorylation
Nucleotide Binding
Regulation Of Apoptotic Process
Cell Death
Nucleoplasm
Apoptotic Process
Programmed Cell Death
Nucleus
Regulation Of Primary Metabolic Process
Protein Modification Process
Post-translational Protein Modification
Regulation Of Metabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Conjugating Enzyme Activity
Regulation Of Macromolecule Metabolic Process
Protein Polyubiquitination
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
SUMO Transferase Activity
Positive Regulation Of Metabolic Process
Cellular Response To Stress
Protein Metabolic Process
PML Body
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Macromolecule Metabolic Process
Transferase Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of RNA Metabolic Process
Cytosol
Negative Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
DNA Damage Response
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Modification Process
Intrinsic Apoptotic Signaling Pathway
Signal Transduction By P53 Class Mediator
Proteolysis Involved In Protein Catabolic Process
Protein Sumoylation
Negative Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
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