ANKRD1 and TRIM63

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (pull down)

		ANKRD1	TRIM63
Gene Name		ankyrin repeat domain 1 (cardiac muscle)	tripartite motif containing 63, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Sarcomere I Band	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding DNA Binding Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding R-SMAD Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Lipid Metabolic Process Small Molecule Metabolic Process Sarcomere Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Biosynthetic Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CASQ2 MYPN TRIM55 TRIM63 TTN	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		27063	84676
HPRD ID		10647	05843
Ensembl ID		ENSG00000148677	ENSG00000158022
Uniprot IDs		Q15327	B4DN95 Q969Q1
PDB IDs			2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Myofibril Assembly Actomyosin Structure Organization Striated Muscle Cell Development Muscle Cell Development Muscle Contraction Striated Muscle Cell Differentiation Muscle System Process Muscle Cell Differentiation Cardiac Muscle Contraction Heart Contraction Organelle Assembly Muscle Structure Development Striated Muscle Contraction Actin Cytoskeleton Organization Actin Filament-based Process Response To Calcium Ion Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Directional Locomotion Sequestering Of Calcium Ion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Anatomical Structure Formation Involved In Morphogenesis Myosin Filament Assembly Cytoskeleton Organization Skeletal Muscle Atrophy Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Blood Circulation Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Cellular Protein Complex Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Cellular Response To Caffeine Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Cellular Response To Organic Cyclic Compound Negative Regulation Of Potassium Ion Transmembrane Transport Cell-cell Signaling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Adult Heart Development	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?		adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocyte cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?		adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocyte cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation	benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?