ANKRD1 and TTN

Number of citations of the paper that reports this interaction (PMID 14583192)
60

Data Source:
HPRD (in vitro, two hybrid)

		ANKRD1	TTN
Gene Name		ankyrin repeat domain 1 (cardiac muscle)	titin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Sarcomere I Band	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Z Disc M Band I Band Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding DNA Binding Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding R-SMAD Binding	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Lipid Metabolic Process Small Molecule Metabolic Process Sarcomere Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Biosynthetic Process	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Blood Coagulation Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Platelet Activation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Striated Muscle Contraction Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Breast size ( 22747683) QT interval ( 20031603)
Protein-Protein Interactions		5 interactors: CASQ2 MYPN TRIM55 TRIM63 TTN	29 interactors: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 VAV2
Entrez ID		27063	7273
HPRD ID		10647	01787
Ensembl ID		ENSG00000148677	ENSG00000155657
Uniprot IDs		Q15327	Q7Z3B7 Q8WZ42
PDB IDs			1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Myofibril Assembly Actomyosin Structure Organization Striated Muscle Cell Development Muscle Cell Development Muscle Contraction Striated Muscle Cell Differentiation Muscle System Process Muscle Cell Differentiation Cardiac Muscle Contraction Heart Contraction Organelle Assembly Muscle Structure Development Striated Muscle Contraction Actin Cytoskeleton Organization Actin Filament-based Process Response To Calcium Ion Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Directional Locomotion Sequestering Of Calcium Ion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Anatomical Structure Formation Involved In Morphogenesis Myosin Filament Assembly Cytoskeleton Organization Skeletal Muscle Atrophy Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Blood Circulation Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Cellular Protein Complex Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Cellular Response To Caffeine Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Cellular Response To Organic Cyclic Compound Negative Regulation Of Potassium Ion Transmembrane Transport Cell-cell Signaling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Adult Heart Development	Muscle Contraction Muscle System Process Muscle Structure Development Actin Filament-based Process Actomyosin Structure Organization Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Myofibril Assembly Striated Muscle Cell Differentiation Striated Muscle Cell Development Actin-mediated Cell Contraction Muscle Cell Development Sarcomere Organization Muscle Organ Development Muscle Cell Differentiation Cellular Component Assembly Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Cytoskeleton Organization Platelet Activation Cell Differentiation Cell Development Organelle Assembly Developmental Process Anatomical Structure Development Organ Development Blood Coagulation Hemostasis System Development Multicellular Organismal Development Platelet Degranulation Striated Muscle Tissue Development Response To Stress Muscle Tissue Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Response To External Stimulus Regulation Of Body Fluid Levels Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Response To Stimulus Wound Healing Cardiovascular System Development Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Intracellular Transport Cell Activation
Tagcloud ?		adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocyte cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation	amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Difference) ?		adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocyte cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation	amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Intersection) ?