ANKRD1 and MYBPC1

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		ANKRD1	MYBPC1
Name		ankyrin repeat domain 1	myosin binding protein C1
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Myofibril I Band Protein-containing Complex	Cytosol Myofibril M Band Myosin Filament
	Molecular Function	P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of DNA Biosynthetic Process	Cell Adhesion Sarcomere Organization
Pathways		PPARA activates gene expression	Striated Muscle Contraction
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Intraocular pressure ( 29617998 ) Refractive error ( 32231278 )	Lung function (FEV1) ( 24023788 ) Memory decline ( 31985465 )
Interacting Genes		23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446	27 interacting genes: ACO1 AMOT ANKRD1 ASH2L C1QTNF9 CALM1 CAPN3 CLIP4 DNAJB5 DNAJB6 DYSF FHL1 FHL2 FHL3 GABARAP GABARAPL1 GABARAPL2 KLHL41 MAP1LC3A MEOX2 MYBPC2 NCF1 RAF1 SGCG TRIM55 TRIM63 TTN
Entrez ID		27063	4604
HPRD ID		10647	01185
Ensembl ID		ENSG00000148677	ENSG00000196091
Uniprot IDs		A0A384NYH5 Q15327	A8KAB1 B3KPP3 Q00872
PDB IDs		Not available	1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM
GO Terms Enriched among Interactors		Z Disc M Band Sarcomere Organization Structural Constituent Of Muscle Muscle Contraction Actin Filament-based Process Actomyosin Structure Organization Muscle System Process Microtubule Actin Cytoskeleton Organization Calcium Ion Binding Titin Binding Contractile Muscle Fiber Muscle Filament Sliding Muscle Alpha-actinin Binding Cytoskeleton Organization Actin-myosin Filament Sliding Microtubule Plus-end Binding Negative Regulation Of Phagocytosis Myosin Filament Microtubule Plus-end I Band Calcium Ion Sequestering Activity Actin-mediated Cell Contraction Monocyte Activation Involved In Immune Response Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity Beta-tubulin Binding Cardiac Muscle Contraction Structural Molecule Activity H Zone Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Limb Development Myofibril Sarcomere Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Condensed Nuclear Chromosome Sarcomerogenesis Bronchus Morphogenesis Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Positive Regulation Of Macropinocytosis N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation	Cellular Response To Nitrogen Starvation Titin Binding Phosphatidylethanolamine Binding Actin Cytoskeleton Organization Z Disc M Band Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Actomyosin Structure Organization Autophagosome Maturation Phospholipid Binding Autophagosome Membrane Mitophagy GABA Receptor Binding Autophagy Of Mitochondrion Organelle Organization Autophagosome Response To Muscle Stretch Myofibril Assembly Autophagosome Assembly Autophagosome Organization Adenylate Cyclase Activator Activity Beta-tubulin Binding Structural Constituent Of Muscle Muscle Organ Development Response To Iron(II) Ion Muscle Structure Development Protein-containing Complex Disassembly Organelle Assembly Cytoplasm Macroautophagy Response To Metal Ion Vacuole Organization Microtubule Cellular Response To Starvation Pseudopodium Response To Starvation Cellular Response To Nutrient Levels Cytosol I Band Supramolecular Fiber Organization Response To Iron Ion Autophagy Response To Calcium Ion Ubiquitin Protein Ligase Binding Anatomical Structure Formation Involved In Morphogenesis Protein Binding Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response