ANKRD1 and ARHGDIB

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		ANKRD1	ARHGDIB
Name		ankyrin repeat domain 1	Rho GDP dissociation inhibitor beta
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Myofibril I Band Protein-containing Complex	Cytoplasm Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding	GTPase Activity Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of DNA Biosynthetic Process	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Cellular Response To Redox State Negative Regulation Of Trophoblast Cell Migration
Pathways		PPARA activates gene expression	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Intraocular pressure ( 29617998 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446	14 interacting genes: ANKRD1 APP CASP3 CDC42 CEBPA EZR RAC1 RAC2 RAC3 RHOA RHOH UBE3A UFM1 VAV1
Entrez ID		27063	397
HPRD ID		10647	04162
Ensembl ID		ENSG00000148677	ENSG00000111348
Uniprot IDs		A0A384NYH5 Q15327	P52566
PDB IDs		Not available	1DS6 5H1D
GO Terms Enriched among Interactors		Z Disc M Band Sarcomere Organization Structural Constituent Of Muscle Muscle Contraction Actin Filament-based Process Actomyosin Structure Organization Muscle System Process Microtubule Actin Cytoskeleton Organization Calcium Ion Binding Titin Binding Contractile Muscle Fiber Muscle Filament Sliding Muscle Alpha-actinin Binding Cytoskeleton Organization Actin-myosin Filament Sliding Microtubule Plus-end Binding Negative Regulation Of Phagocytosis Myosin Filament Microtubule Plus-end I Band Calcium Ion Sequestering Activity Actin-mediated Cell Contraction Monocyte Activation Involved In Immune Response Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity Beta-tubulin Binding Cardiac Muscle Contraction Structural Molecule Activity H Zone Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Limb Development Myofibril Sarcomere Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Condensed Nuclear Chromosome Sarcomerogenesis Bronchus Morphogenesis Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Positive Regulation Of Macropinocytosis N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation	Intracellular Signal Transduction Intracellular Signaling Cassette Actin Filament Organization Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Establishment Or Maintenance Of Cell Polarity Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Immune System Process Cortical Cytoskeleton Organization Regulation Of Cell Adhesion GTPase Activity Chemotaxis Signal Transduction Regulation Of Actin Cytoskeleton Organization Locomotion GTP Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction G Protein Activity Regulation Of Actin Filament-based Process Establishment Of Epithelial Cell Apical/basal Polarity NADPH Oxidase Complex Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-substrate Adhesion Respiratory Burst Cerebral Cortex GABAergic Interneuron Development Cellular Developmental Process Establishment Of Apical/basal Cell Polarity Regulation Of Leukocyte Migration Postsynapse Endocytosis Polarized Epithelial Cell Differentiation Protein Kinase Binding Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Periphery Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Metabolic Process Developmental Process Positive Regulation Of Cell Adhesion Establishment Of Epithelial Cell Polarity Regulation Of Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Vesicle-mediated Transport Response To Cytokine Positive Regulation Of Lamellipodium Organization Regulation Of Synapse Organization