ANKRD1 and ZNF446

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKRD1	ZNF446
Description		ankyrin repeat domain 1	zinc finger protein 446
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Myofibril I Band Protein-containing Complex	Chromatin Extracellular Space Nucleus
	Molecular Function	P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of DNA Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		PPARA activates gene expression	Generic Transcription Pathway
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Refractive error ( 32231278)	Obesity-related traits ( 23251661) Uric acid clearance ( 28095793)
Interacting Genes		23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446	54 interacting genes: ACTN2 ANKRD1 CCNK COPS2 CYSRT1 DGCR6 DGCR6L EHMT2 EVI5 FHL5 FRMD8 FRS3 GOLGA6L9 INCA1 KIFC3 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP3-1 LNX1 LZTS2 MAGOHB MDFI NBPF19 NOTCH2NLA PIN1 REL SCAND1 SIVA1 SUFU TAX1BP1 TRIM27 UBE2I UBE3A ZKSCAN7 ZNF165 ZNF18 ZNF232 ZNF24 ZNF263 ZNF496 ZSCAN12 ZSCAN16 ZSCAN18 ZSCAN21 ZSCAN22 ZSCAN29 ZSCAN30 ZSCAN32 ZSCAN9
Entrez ID		27063	55663
HPRD ID		10647	07934
Ensembl ID		ENSG00000148677	ENSG00000083838
Uniprot IDs		A0A384NYH5 Q15327	Q9NWS9
PDB IDs
Enriched GO Terms of Interacting Partners?		Z Disc M Band Sarcomere Organization Structural Constituent Of Muscle Muscle Contraction Actin Filament-based Process Actomyosin Structure Organization Muscle System Process Microtubule Actin Cytoskeleton Organization Calcium Ion Binding Titin Binding Contractile Muscle Fiber Muscle Filament Sliding Muscle Alpha-actinin Binding Cytoskeleton Organization Actin-myosin Filament Sliding Microtubule Plus-end Binding Negative Regulation Of Phagocytosis Myosin Filament Microtubule Plus-end I Band Calcium Ion Sequestering Activity Actin-mediated Cell Contraction Monocyte Activation Involved In Immune Response Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity Beta-tubulin Binding Cardiac Muscle Contraction Structural Molecule Activity H Zone Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Limb Development Myofibril Sarcomere Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Condensed Nuclear Chromosome Sarcomerogenesis Bronchus Morphogenesis Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Positive Regulation Of Macropinocytosis N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Keratin Filament Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Regulation Of Gene Expression Structural Constituent Of Skin Epidermis Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Binding Nucleus Regulation Of Metabolic Process Intermediate Filament Organization Metal Ion Binding Postsynaptic Cytosol Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Molecule Activity Protein Binding Sequence-specific Double-stranded DNA Binding Titin Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?