ANKRD1 and CASQ2

Number of citations of the paper that reports this interaction (PMID 15698842)
6

Data Source:
HPRD (in vitro)

		ANKRD1	CASQ2
Gene Name		ankyrin repeat domain 1 (cardiac muscle)	calsequestrin 2 (cardiac muscle)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Sarcomere I Band	Intracellular Cytoplasm Voltage-gated Calcium Channel Complex Junctional Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding DNA Binding Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding R-SMAD Binding	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Lipid Metabolic Process Small Molecule Metabolic Process Sarcomere Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Biosynthetic Process	Regulation Of Heart Rate Detection Of Calcium Ion Striated Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Sarcomere Organization Sequestering Of Calcium Ion Protein Polymerization Transmembrane Transport Cardiac Muscle Contraction Regulation Of Membrane Repolarization Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS			Ventricular conduction ( 21076409)
Protein-Protein Interactions		5 interactors: CASQ2 MYPN TRIM55 TRIM63 TTN	4 interactors: ANKRD1 CSNK2A1 CSNK2A2 TRDN
Entrez ID		27063	845
HPRD ID		10647	00256
Ensembl ID		ENSG00000148677	ENSG00000118729
Uniprot IDs		Q15327	B4DEF0 B4DIB0 O14958
PDB IDs			2VAF
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Myofibril Assembly Actomyosin Structure Organization Striated Muscle Cell Development Muscle Cell Development Muscle Contraction Striated Muscle Cell Differentiation Muscle System Process Muscle Cell Differentiation Cardiac Muscle Contraction Heart Contraction Organelle Assembly Muscle Structure Development Striated Muscle Contraction Actin Cytoskeleton Organization Actin Filament-based Process Response To Calcium Ion Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Directional Locomotion Sequestering Of Calcium Ion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Anatomical Structure Formation Involved In Morphogenesis Myosin Filament Assembly Cytoskeleton Organization Skeletal Muscle Atrophy Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Blood Circulation Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Cellular Protein Complex Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Cellular Response To Caffeine Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Cellular Response To Organic Cyclic Compound Negative Regulation Of Potassium Ion Transmembrane Transport Cell-cell Signaling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Adult Heart Development	Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Endoplasmic Reticulum Membrane Organization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Striated Muscle Cell Differentiation Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Division Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Communication By Electrical Coupling Wnt Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Cell Differentiation Generation Of Neurons Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Proteolysis Neurogenesis Response To Muscle Stretch Regulation Of Cardiac Muscle Cell Membrane Potential Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Axon Guidance Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Protein Processing Cell Development Response To External Stimulus Regulation Of Mitotic Cell Cycle
Tagcloud ?		adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocyte cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation	3d aligned alphamhc averaged cardiomyocyte cd172a cms contractile ctnt cvs dissociated ec50 embryoid esc fibrin hes2 hesc inotropy isoproterenol monolayers nn patch patches purity sarcomeres serca2 sirpa uniformly velocities
Tagcloud (Difference) ?		adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation	3d aligned alphamhc averaged cd172a cms contractile ctnt cvs dissociated ec50 embryoid esc fibrin hes2 hesc inotropy isoproterenol monolayers nn patch patches purity sarcomeres serca2 sirpa uniformly velocities
Tagcloud (Intersection) ?		cardiomyocyte