GAS2 and ACTA1

Number of citations of the paper that reports this interaction (PMID 10564664)
9

Data Source:
HPRD (in vitro)

		GAS2	ACTA1
Gene Name		growth arrest-specific 2	actin, alpha 1, skeletal muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Filament Membrane	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function		Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Arrest Regulation Of Cell Shape	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Striated Muscle Contraction
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		3 interactors: ACTA1 APP CAPN2	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		2620	58
HPRD ID		04158	00030
Ensembl ID		ENSG00000148935	ENSG00000143632
Uniprot IDs		O43903	P68133 Q5T8M7
PDB IDs			1T44
Enriched GO Terms of Interacting Partners?		Myotube Differentiation Response To Abiotic Stimulus Cell Growth Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Striated Muscle Cell Differentiation Collateral Sprouting In Absence Of Injury Muscle Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Anatomical Structure Morphogenesis Neuron Remodeling Skeletal Muscle Adaptation Protein Autoprocessing Growth Muscle Structure Development Cellular Copper Ion Homeostasis Myoblast Fusion Copper Ion Homeostasis Suckling Behavior Skeletal Muscle Fiber Development Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Myotube Cell Development Neuron Maturation MRNA Polyadenylation Response To Lithium Ion Regulation Of Epidermal Growth Factor-activated Receptor Activity Actin-myosin Filament Sliding Muscle Filament Sliding Mating Behavior Syncytium Formation Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Actin-mediated Cell Contraction Ionotropic Glutamate Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Muscle Fiber Development Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		15q13 acetylcholine acra7 bungarotoxin chicken clones cm d7mit70 distal electrophysiologic encodes homologous hras1 identity igf1r isolation mapped myod1 nicotine nicotinic proximal ps1 q14 relevance schizophrenia snrp2a substantial subunit symbol	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		15q13 acetylcholine acra7 bungarotoxin chicken clones cm d7mit70 distal electrophysiologic encodes homologous hras1 identity igf1r isolation mapped myod1 nicotine nicotinic proximal ps1 q14 relevance schizophrenia snrp2a substantial subunit symbol	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?