GAS2 and CAPN2

Number of citations of the paper that reports this interaction (PMID 11387205)
13

Data Source:
HPRD (in vivo)

		GAS2	CAPN2
Gene Name		growth arrest-specific 2	calpain 2, (m/II) large subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Filament Membrane	Chromatin Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Dendrite Cortical Actin Cytoskeleton Pseudopodium Membrane Raft Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum
	Molecular Function		Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Protein Heterodimerization Activity
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Arrest Regulation Of Cell Shape	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Protein Autoprocessing Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Amino Acid Stimulus
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		3 interactors: ACTA1 APP CAPN2	17 interactors: ADRBK1 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 F2RL1 GAS2 KNG1 MAPK1 MAPT NFKBIA NMT1 PTPN1 PTPRN TNS1
Entrez ID		2620	824
HPRD ID		04158	00254
Ensembl ID		ENSG00000148935	ENSG00000162909
Uniprot IDs		O43903	B4DN77 P17655 Q59EF6
PDB IDs			1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?		Myotube Differentiation Response To Abiotic Stimulus Cell Growth Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Striated Muscle Cell Differentiation Collateral Sprouting In Absence Of Injury Muscle Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Anatomical Structure Morphogenesis Neuron Remodeling Skeletal Muscle Adaptation Protein Autoprocessing Growth Muscle Structure Development Cellular Copper Ion Homeostasis Myoblast Fusion Copper Ion Homeostasis Suckling Behavior Skeletal Muscle Fiber Development Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Myotube Cell Development Neuron Maturation MRNA Polyadenylation Response To Lithium Ion Regulation Of Epidermal Growth Factor-activated Receptor Activity Actin-myosin Filament Sliding Muscle Filament Sliding Mating Behavior Syncytium Formation Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Actin-mediated Cell Contraction Ionotropic Glutamate Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Muscle Fiber Development Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition	Regulation Of Cellular Localization Regulation Of Intracellular Transport Positive Regulation Of Transport Peptidyl-threonine Phosphorylation Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Peptidyl-serine Phosphorylation Defense Response Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Localization Response To Estrogen Neurotrophin TRK Receptor Signaling Pathway Response To Steroid Hormone Immune Response Neurotrophin Signaling Pathway Response To Lipid Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Intracellular Transport Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Regulation Of Cellular Protein Metabolic Process Response To Stress Establishment Of Localization In Cell Pons Development Response To Hormone Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Mitochondrion Organization Protein Metabolic Process Renal System Process G-protein Coupled Acetylcholine Receptor Signaling Pathway
Tagcloud ?		15q13 acetylcholine acra7 bungarotoxin chicken clones cm d7mit70 distal electrophysiologic encodes homologous hras1 identity igf1r isolation mapped myod1 nicotine nicotinic proximal ps1 q14 relevance schizophrenia snrp2a substantial subunit symbol	1h basilar camk2a camk2b capn1 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rab3b rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
Tagcloud (Difference) ?		15q13 acetylcholine acra7 bungarotoxin chicken clones cm d7mit70 distal electrophysiologic encodes homologous hras1 identity igf1r isolation mapped myod1 nicotine nicotinic proximal ps1 q14 relevance schizophrenia snrp2a substantial subunit symbol	1h basilar camk2a camk2b capn1 cisplatin cochlea deacetylases ganglion hair hdacs immunocytochemistry label neurofilament neurotransmitter newborn organotypic ototoxicity panther phalloidin rab3b rhodamine sgns snap25 spiral tnfrsf1a trichostatin tsa vglut1
Tagcloud (Intersection) ?