GAS2 and TBC1D21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GAS2	TBC1D21
Description		growth arrest specific 2	TBC1 domain family member 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Actin Filament Membrane	Acrosomal Vesicle Cytoplasm Cytoskeleton Cytoplasmic Vesicle Extracellular Exosome Sperm Midpiece
	Molecular Function	Protein Binding Microtubule Binding Actin Filament Binding	Actin Binding GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Apoptotic Process Regulation Of Cell Shape Regulation Of Notch Signaling Pathway Ovulation Regulation Of Cell Cycle Actin Crosslink Formation Basement Membrane Organization	Spermatogenesis Sperm Axoneme Assembly Cell Differentiation Flagellated Sperm Motility Plasma Membrane To Endosome Transport Sperm Mitochondrial Sheath Assembly Regulation Of Cilium Assembly
Pathways		Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)	Coffee consumption (cups per day) ( 31837886) Estimated glomerular filtration rate ( 31152163) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Feeling fed-up ( 29500382) Glucose homeostasis traits ( 25524916) LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		4 interacting genes: ACTA1 APP CAPN2 TBC1D21	29 interacting genes: APP CCDC158 CFAP53 EVI5L GAS2 GFAP GTF2E1 KIF26A KRT15 KRT35 KRT37 KRT38 KRT40 LCN2 MEOX2 NR1D2 NUTM1 PDCD2 PMF1 PMF1-BGLAP RAB3IP REL RIBC1 SAMD4A SEPTIN2 SNX7 STMN3 TCF12 TIMM10
Entrez ID		2620	161514
HPRD ID		04158	15473
Ensembl ID		ENSG00000148935	ENSG00000167139
Uniprot IDs		O43903	Q8IYX1
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cell Body Mesenchyme Migration Acetylcholine Receptor Activator Activity Membrane Raft Amyloid-beta Complex PTB Domain Binding Presynapse Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Postsynapse Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Regulation Of Interleukin-6 Production Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Response To Mechanical Stimulus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phosphatidylcholine Biosynthetic Process Calpain Complex Protein Catabolic Process At Postsynapse Regulation Of Phosphatidylcholine Biosynthetic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Sperm Mitochondrial Sheath Assembly Skeletal Muscle Thin Filament Assembly Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Reproductive Process Heparan Sulfate Binding	Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Keratin Filament Cytoskeleton Structural Molecule Activity Regulation Of Cell Projection Organization Astrocyte Projection Morphogenesis Of An Epithelium Negative Regulation Of Cell Projection Organization Regulation Of Neurotransmitter Uptake Epithelial Cell Differentiation Tissue Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonemal A Tubule Inner Sheath
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