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UPF2 and TK1
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
BioGRID
(two hybrid)
UPF2
TK1
Description
UPF2 regulator of nonsense mediated mRNA decay
thymidine kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Exon-exon Junction Complex
Cytoplasmic Ribonucleoprotein Granule
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Cytosol
Molecular Function
RNA Binding
Protein Binding
Telomeric DNA Binding
Nucleotide Binding
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Liver Development
MRNA Export From Nucleus
Animal Organ Regeneration
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Thymidine Metabolic Process
Thymidine Biosynthetic Process
Protein Homotetramerization
DNA Biosynthetic Process
DNA Synthesis Involved In Mitotic DNA Replication
Pathways
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
G1/S-Specific Transcription
Pyrimidine salvage
Drugs
Dithioerythritol
Thymidine 5'-triphosphate
Diseases
GWAS
Diverticular disease (
30177863
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
27863252
28957414
32888494
)
Interacting Genes
76 interacting genes:
ABCF2
AGPAT1
AKTIP
ART4
ATP1B3
BLM
CALR
CENPU
CIZ1
COMTD1
CYBA
DCP1B
DCP2
DPF2
E4F1
EIF1
EIF4A1
EIF4G1
ENO1
EXOSC1
EXOSC10
EXOSC4
EXOSC6
EXOSC8
GADD45GIP1
HBZ
HMGA1
HS3ST3A1
HSF2BP
ITGB1
KRT18
LDHA
LSM1
MAP1A
MAP1LC3B
MIF
MRPL40
MTERF3
MTREX
MYB
NDUFA7
NOB1
NOMO1
NOP53
PHB2
PITX1
PUF60
RNPS1
RPL13
RPL5
RPL8
RPS15
RPS25
RPS6
RPS7
RRP7A
RSRC2
SERBP1
SERF2
SMG1
SUMO3
TK1
TNNI2
TOP3B
TUBB2A
TYMS
UPF1
UPF3B
WNK1
XRN1
XRN2
ZBTB48
ZFP36
ZGPAT
ZNF408
ZNF44
166 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CFTR
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
FZR1
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PRMT1
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UBC
UNC119
UPF2
USP4
VMA22
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
Entrez ID
26019
7083
HPRD ID
10405
01771
Ensembl ID
ENSG00000151461
ENSG00000167900
Uniprot IDs
Q9HAU5
A0A384MDV9
K7ERV3
K7ES52
P04183
PDB IDs
1UW4
2WJV
4CEK
4CEM
7NWU
7QG6
1W4R
1XBT
2ORV
2WVJ
Enriched GO Terms of Interacting Partners
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RNA Binding
Nuclear-transcribed MRNA Catabolic Process
RNA Catabolic Process
MRNA Catabolic Process
Nucleobase-containing Compound Catabolic Process
RRNA Metabolic Process
RRNA Processing
Nucleic Acid Metabolic Process
Exosome (RNase Complex)
Nucleus
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
RNA Metabolic Process
Histone MRNA Catabolic Process
Nuclear Exosome (RNase Complex)
Negative Regulation Of Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nucleolar Exosome (RNase Complex)
Negative Regulation Of Macromolecule Biosynthetic Process
Nuclear MRNA Surveillance
Ribosome
Histone MRNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Cytoplasmic Exosome (RNase Complex)
RNA Exonuclease Activity
Regulation Of Gene Expression
Ribonucleoprotein Complex Biogenesis
Regulation Of Macromolecule Biosynthetic Process
MRNA Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
RNA Processing
Ribosomal Small Subunit Biogenesis
Translation
Regulation Of Macromolecule Metabolic Process
Ribonucleoprotein Complex
Nucleolus
Nucleic Acid Binding
Cytosolic Ribosome
Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
5'-3' RNA Exonuclease Activity
Regulation Of Metabolic Process
Nuclear RNA Surveillance
RRNA Catabolic Process
RNA Surveillance
DNA Metabolic Process
Cytosol
Cytoplasmic Translation
Negative Regulation Of Protein Metabolic Process
Macromolecule Catabolic Process
Cytoplasm
Macromolecule Metabolic Process
Protein Metabolic Process
Platelet Alpha Granule Lumen
Chromatin Organization
Blood Microparticle
Negative Regulation Of Cell Cycle G1/S Phase Transition
Chromatin Remodeling
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Cytosol
Regulation Of DNA Replication
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Binding
Nucleoplasm
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nuclear Matrix
Regulation Of Protein Catabolic Process
DNA Synthesis Involved In Mitotic DNA Replication
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Positive Regulation Of Protein Metabolic Process
Cytoskeleton
Negative Regulation Of Cell Cycle Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein Tag Activity
Developmental Process
Growth Cone
Protein Modification Process
Cellular Response To Norepinephrine Stimulus
Response To Norepinephrine
Mitotic DNA Damage Checkpoint Signaling
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Oocyte Growth
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Tagcloud (Difference)
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Tagcloud (Intersection)
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