UPF2 and MAP1A

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		UPF2	MAP1A
Description		UPF2 regulator of nonsense mediated mRNA decay	microtubule associated protein 1A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Axon Dendrite Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Dendritic Branch Synapse Primary Dendrite Dendritic Microtubule Axon Cytoplasm
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	Actin Binding Structural Molecule Activity Protein Binding Microtubule Binding Cytoskeletal Anchor Activity Tubulin Binding Tau Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	Microtubule Cytoskeleton Organization Axonogenesis Memory Associative Learning Dendrite Development Regulation Of Microtubule Depolymerization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Synaptic Plasticity Voluntary Musculoskeletal Movement Neuron Cellular Homeostasis Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Protein Localization Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Estramustine
Diseases
GWAS		Diverticular disease ( 30177863)	Hemoglobin levels ( 32327693) Platelet count ( 27863252) Plateletcrit ( 27863252) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818) Triglycerides ( 24507774 30275531)
Interacting Genes		76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	28 interacting genes: ACTA1 ACTG1 AP1G1 ARHGEF11 CACNB4 CSNK2A1 DISC1 DLG1 DLG2 DLG4 GRB2 HTR2A KCNMA1 MAP1B MAP1LC3A NXF1 NXF2 OGT PRKAR1A RAPGEF3 RAPGEF4 RHOB SFN SPP1 TUBA4A TUBB UPF2 WEE2-AS1
Entrez ID		26019	4130
HPRD ID		10405	02549
Ensembl ID		ENSG00000151461	ENSG00000166963
Uniprot IDs		Q9HAU5	E9PGC8 P78559 Q504X9
PDB IDs		1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process	Synapse Cytosol Glutamatergic Synapse Protein Kinase Binding Intracellular Protein Localization Organelle Organization Cellular Localization Regulation Of Transport Establishment Or Maintenance Of Cell Polarity CAMP Binding Neuromuscular Junction Regulation Of Cellular Component Organization Protein Localization To Cell Junction Intracellular Transport Intracellular Signal Transduction Establishment Of Localization In Cell Regulation Of Biological Quality Ionotropic Glutamate Receptor Binding Microtubule Muscle Contraction Cytoskeleton Organization Structural Constituent Of Cytoskeleton Regulation Of Secretion By Cell Presynapse Axon Regulation Of Cell Growth Non-canonical Inflammasome Complex Assembly Muscle System Process Regulation Of Secretion Intracellular Signaling Cassette Postsynaptic Density Nuclear Export Odontoblast Differentiation Nuclear RNA Export Factor Complex Small GTPase-mediated Signal Transduction Positive Regulation Of Protein Localization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Urinary Bladder Smooth Muscle Contraction Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity GMP Kinase Activity Smooth Muscle Contraction Regulation Of Synapse Organization Protein Localization To Synapse Positive Regulation Of Cell Growth Chemical Synaptic Transmission GDP Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Juxtaparanode Region Of Axon
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