UPF2 and NOB1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		UPF2	NOB1
Gene Name		UPF2 regulator of nonsense transcripts homolog (yeast)	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	RNA Binding Protein Binding	Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Gene Expression Organ Regeneration	Visual Perception
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		75 interactors: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GLTSCR2 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MYB NDUFA7 NOB1 NOMO1 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SKIV2L2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	3 interactors: APP PRNP UPF2
Entrez ID		26019	28987
HPRD ID		10405	11395
Ensembl ID		ENSG00000151461	ENSG00000141101
Uniprot IDs		Q9HAU5	Q9ULX3
PDB IDs		1UW4 2WJV
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Histone MRNA Catabolic Process RRNA Processing Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Translational Initiation Viral Process Ribosome Biogenesis Biosynthetic Process Histone MRNA Metabolic Process Cellular Metabolic Process Translational Termination Protein Complex Disassembly Translational Elongation RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Protein Complex Disassembly Viral Transcription NcRNA Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Metabolic Process Establishment Of Protein Localization To Membrane Translation Protein Targeting To Membrane Nuclear MRNA Surveillance Protein Localization To Membrane	Cellular Copper Ion Homeostasis Copper Ion Homeostasis Transition Metal Ion Homeostasis Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Learning Or Memory Cognition Negative Regulation Of Calcineurin-NFAT Signaling Cascade Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Copper Ion Axon Choice Point Recognition Negative Regulation Of Calcium-mediated Signaling Axon Guidance Cellular Metal Ion Homeostasis Response To Oxidative Stress Cellular Cation Homeostasis Single-organism Behavior Cellular Ion Homeostasis Neuron Remodeling Negative Regulation Of Interleukin-17 Production Metal Ion Homeostasis Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Activated T Cell Proliferation Axonogenesis Cellular Chemical Homeostasis MRNA Metabolic Process Ion Homeostasis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Chemotaxis Neuron Projection Morphogenesis Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Receptor Signaling Pathway Cellular Homeostasis Response To Copper Ion Cell Morphogenesis Involved In Differentiation Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Projection Morphogenesis Chemical Homeostasis Cell Part Morphogenesis Negative Regulation Of Protein Metabolic Process
Tagcloud ?		achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi	a549 anticancer assembly biomarker carrying colony constructed counterparts critically define devastating diagnostic downregulation formulate initially lentiviral lethal nin nsclc nude quantitive ribosome rpn12 shrna silencing suppressed tumorigenesis tumorigenic vector
Tagcloud (Difference) ?		achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi	a549 anticancer assembly biomarker carrying colony constructed counterparts critically define devastating diagnostic downregulation formulate initially lentiviral lethal nin nsclc nude quantitive ribosome rpn12 shrna silencing suppressed tumorigenesis tumorigenic vector
Tagcloud (Intersection) ?