UPF2 and RPS7

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		UPF2	RPS7
Gene Name		UPF2 regulator of nonsense transcripts homolog (yeast)	ribosomal protein S7
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Ribosome Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex 90S Preribosome Small-subunit Processome Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Gene Expression Organ Regeneration	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Small Subunit Biogenesis Cellular Protein Metabolic Process
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		75 interactors: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GLTSCR2 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MYB NDUFA7 NOB1 NOMO1 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SKIV2L2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	9 interactors: CDKN2A IPO5 IPO7 MDM2 NEK6 RPS4X TNPO1 UPF2 ZBTB14
Entrez ID		26019	6201
HPRD ID		10405	04712
Ensembl ID		ENSG00000151461	ENSG00000171863
Uniprot IDs		Q9HAU5	P62081
PDB IDs		1UW4 2WJV	3J3A
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Histone MRNA Catabolic Process RRNA Processing Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Translational Initiation Viral Process Ribosome Biogenesis Biosynthetic Process Histone MRNA Metabolic Process Cellular Metabolic Process Translational Termination Protein Complex Disassembly Translational Elongation RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Protein Complex Disassembly Viral Transcription NcRNA Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Metabolic Process Establishment Of Protein Localization To Membrane Translation Protein Targeting To Membrane Nuclear MRNA Surveillance Protein Localization To Membrane	Protein Localization To Nucleus Protein Localization To Organelle Viral Process Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Establishment Of Protein Localization To Organelle Protein Import Into Nucleus Nuclear Import Protein Targeting Protein Import Protein Destabilization Regulation Of Cellular Senescence Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Cellular Protein Localization Regulation Of Mitotic Cell Cycle Phase Transition Cellular Localization Regulation Of Cell Cycle Phase Transition Establishment Of Protein Localization Regulation Of Intracellular Protein Transport Intracellular Transport Regulation Of Signal Transduction By P53 Class Mediator Intracellular Protein Transport Protein Localization Positive Regulation Of Cell Cycle Arrest Cellular Response To UV-C Cellular Response To Vitamin B1 Establishment Of Localization In Cell Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Transport Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cell Cycle Arrest Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Regulation Of Response To DNA Damage Stimulus Senescence-associated Heterochromatin Focus Assembly Protein Transport Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Transport Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Intracellular Protein Transport Traversing Start Control Point Of Mitotic Cell Cycle Positive Regulation Of Cellular Senescence DNA Damage Checkpoint MRNA Catabolic Process Regulation Of Proteolysis
Tagcloud ?		achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi	3gamma assisted bmecs bovine coimmunoprecipitation coip colocalization desorption eif1ax fingerprinting flight fret interacted ionization isoform maldi mammary methionine mtor positively promote proved resonance stat5 synthesis tof translation trigger triggered
Tagcloud (Difference) ?		achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi	3gamma assisted bmecs bovine coimmunoprecipitation coip colocalization desorption eif1ax fingerprinting flight fret interacted ionization isoform maldi mammary methionine mtor positively promote proved resonance stat5 synthesis tof translation trigger triggered
Tagcloud (Intersection) ?