UPF2 and DPF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		UPF2	DPF2
Description		UPF2 regulator of nonsense mediated mRNA decay	double PHD fingers 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SWI/SNF Complex NBAF Complex
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity Histone H3K14ac Reader Activity Histone H4K16ac Reader Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of G0 To G1 Transition Apoptotic Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)	Acne (severe) ( 24927181) Mean spheric corpuscular volume ( 32888494) Urate levels ( 31578528)
Interacting Genes		76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	20 interacting genes: FHL2 GOLGA6L9 H3-4 H3C1 H4C1 HSF2BP LDOC1 LNX1 MEOX2 NFKB2 PICK1 REL RELB RINT1 RUBCN TTC23L TXNDC12 UPF2 ZNF212 ZNF655
Entrez ID		26019	5977
HPRD ID		10405	03394
Ensembl ID		ENSG00000151461	ENSG00000133884
Uniprot IDs		Q9HAU5	J3KMZ8 Q92785
PDB IDs		1UW4 2WJV 4CEK 4CEM 7NWU 7QG6	3IUF 5B79 5VDC 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?		RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process	NF-kappaB Complex Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interferon-beta Production Structural Constituent Of Chromatin Response To Muramyl Dipeptide Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm
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