UBR2 and HIST2H2AC

Number of citations of the paper that reports this interaction (PMID 22616001)
2

Data Source:
BioGRID (enzymatic study)

		UBR2	HIST2H2AC
Gene Name		ubiquitin protein ligase E3 component n-recognin 2	histone cluster 2, H2ac
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleoplasm Plasma Membrane	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Leucine Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Male Meiosis I Spermatogenesis Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine	Biological_process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: HIST1H2BG HIST2H2AC UBE2B UBE2H	65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46
Entrez ID		23304	8338
HPRD ID		09853	09107
Ensembl ID		ENSG00000024048	ENSG00000184260
Uniprot IDs		B3KXG6 Q8IWV8	Q16777
PDB IDs		3NY2 3NY3
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Negative Regulation Of Histone Phosphorylation Positive Regulation Of Reciprocal Meiotic Recombination Maintenance Of Chromatin Silencing Positive Regulation Of Meiosis I Negative Regulation Of CAMP-mediated Signaling Chiasma Assembly Regulation Of Meiosis I Sperm Axoneme Assembly Histone H2A Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response In Mucosa Positive Regulation Of Meiotic Nuclear Division Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Postreplication Repair Regulation Of CAMP-mediated Signaling Axoneme Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Synaptonemal Complex Organization Antibacterial Humoral Response Antimicrobial Humoral Response Chromatin Organization Mucosal Immune Response Protein K63-linked Ubiquitination Histone Lysine Demethylation Chromatin Silencing Histone Ubiquitination Histone Demethylation Protein Demethylation Protein Monoubiquitination Regulation Of Meiosis Protein Autoubiquitination Cellular Macromolecule Catabolic Process Reciprocal Meiotic Recombination Microtubule Bundle Formation Regulation Of Meiotic Cell Cycle Synapsis Homologous Chromosome Segregation Chromosome Organization Demethylation Defense Response To Gram-positive Bacterium Regulation Of DNA Recombination	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly
Tagcloud ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting
Tagcloud (Difference) ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting
Tagcloud (Intersection) ?