UBR2 and UBE2H

Number of citations of the paper that reports this interaction (PMID 22616001)
2

Data Source:
BioGRID (pull down)

		UBR2	UBE2H
Gene Name		ubiquitin protein ligase E3 component n-recognin 2	ubiquitin-conjugating enzyme E2H
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleoplasm Plasma Membrane	Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Leucine Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Male Meiosis I Spermatogenesis Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine	Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: HIST1H2BG HIST2H2AC UBE2B UBE2H	57 interactors: BRAP BYSL CBLC CD99 DTX3 DTX3L DZIP3 EPS15 HDAC6 HIST2H2AA3 JADE1 LRSAM1 MARCH1 MARCH10 MARCH2 MARCH4 MARCH8 MKRN3 NEURL1 NHLRC1 POLL POLM RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 UBA1 UBASH3B UBOX5 UBR2
Entrez ID		23304	7328
HPRD ID		09853	03052
Ensembl ID		ENSG00000024048	ENSG00000186591
Uniprot IDs		B3KXG6 Q8IWV8	A4D1L5 P62256
PDB IDs		3NY2 3NY3	2Z5D
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Negative Regulation Of Histone Phosphorylation Positive Regulation Of Reciprocal Meiotic Recombination Maintenance Of Chromatin Silencing Positive Regulation Of Meiosis I Negative Regulation Of CAMP-mediated Signaling Chiasma Assembly Regulation Of Meiosis I Sperm Axoneme Assembly Histone H2A Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response In Mucosa Positive Regulation Of Meiotic Nuclear Division Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Postreplication Repair Regulation Of CAMP-mediated Signaling Axoneme Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Synaptonemal Complex Organization Antibacterial Humoral Response Antimicrobial Humoral Response Chromatin Organization Mucosal Immune Response Protein K63-linked Ubiquitination Histone Lysine Demethylation Chromatin Silencing Histone Ubiquitination Histone Demethylation Protein Demethylation Protein Monoubiquitination Regulation Of Meiosis Protein Autoubiquitination Cellular Macromolecule Catabolic Process Reciprocal Meiotic Recombination Microtubule Bundle Formation Regulation Of Meiotic Cell Cycle Synapsis Homologous Chromosome Segregation Chromosome Organization Demethylation Defense Response To Gram-positive Bacterium Regulation Of DNA Recombination	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Protein Catabolic Process Histone Monoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Regulation Of Viral Entry Into Host Cell Cellular Macromolecule Catabolic Process Cellular Process Negative Regulation Of Protein Metabolic Process Histone Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Viral Process Regulation Of ERBB Signaling Pathway Protein Trimerization Aggresome Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K6-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromatin Modification Negative Regulation Of Cellular Protein Metabolic Process Proteolysis Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Negative Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting	0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Difference) ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting	0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Intersection) ?