UBR2

Gene Name		ubiquitin protein ligase E3 component n-recognin 2
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleoplasm Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Leucine Binding
	Biological Process	Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Male Meiosis I Spermatogenesis Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		4 interactors: HIST1H2BG HIST2H2AC UBE2B UBE2H
Entrez ID		23304
HPRD ID		09853
Ensembl ID		ENSG00000024048
Uniprot IDs		B3KXG6 Q8IWV8
PDB IDs		3NY2 3NY3
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Negative Regulation Of Histone Phosphorylation Positive Regulation Of Reciprocal Meiotic Recombination Maintenance Of Chromatin Silencing Positive Regulation Of Meiosis I Negative Regulation Of CAMP-mediated Signaling Chiasma Assembly Regulation Of Meiosis I Sperm Axoneme Assembly Histone H2A Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response In Mucosa Positive Regulation Of Meiotic Nuclear Division Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Postreplication Repair Regulation Of CAMP-mediated Signaling Axoneme Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Synaptonemal Complex Organization Antibacterial Humoral Response Antimicrobial Humoral Response Chromatin Organization Mucosal Immune Response Protein K63-linked Ubiquitination Histone Lysine Demethylation Chromatin Silencing Histone Ubiquitination Histone Demethylation Protein Demethylation Protein Monoubiquitination Regulation Of Meiosis Protein Autoubiquitination Cellular Macromolecule Catabolic Process Reciprocal Meiotic Recombination Microtubule Bundle Formation Regulation Of Meiotic Cell Cycle Synapsis Homologous Chromosome Segregation Chromosome Organization Demethylation Defense Response To Gram-positive Bacterium Regulation Of DNA Recombination
Tagcloud ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting