UBR2 and HIST1H2BG

Number of citations of the paper that reports this interaction (PMID 22616001)
2

Data Source:
BioGRID (enzymatic study)

		UBR2	HIST1H2BG
Gene Name		ubiquitin protein ligase E3 component n-recognin 2	histone cluster 1, H2bg
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleoplasm Plasma Membrane	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Leucine Binding	DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Male Meiosis I Spermatogenesis Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: HIST1H2BG HIST2H2AC UBE2B UBE2H	5 interactors: PTMA RAD51B TGM2 UBR2 YWHAQ
Entrez ID		23304	8339
HPRD ID		09853	11897
Ensembl ID		ENSG00000024048	ENSG00000187990
Uniprot IDs		B3KXG6 Q8IWV8	B2R4S9 P62807
PDB IDs		3NY2 3NY3
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Negative Regulation Of Histone Phosphorylation Positive Regulation Of Reciprocal Meiotic Recombination Maintenance Of Chromatin Silencing Positive Regulation Of Meiosis I Negative Regulation Of CAMP-mediated Signaling Chiasma Assembly Regulation Of Meiosis I Sperm Axoneme Assembly Histone H2A Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response In Mucosa Positive Regulation Of Meiotic Nuclear Division Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Postreplication Repair Regulation Of CAMP-mediated Signaling Axoneme Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Synaptonemal Complex Organization Antibacterial Humoral Response Antimicrobial Humoral Response Chromatin Organization Mucosal Immune Response Protein K63-linked Ubiquitination Histone Lysine Demethylation Chromatin Silencing Histone Ubiquitination Histone Demethylation Protein Demethylation Protein Monoubiquitination Regulation Of Meiosis Protein Autoubiquitination Cellular Macromolecule Catabolic Process Reciprocal Meiotic Recombination Microtubule Bundle Formation Regulation Of Meiotic Cell Cycle Synapsis Homologous Chromosome Segregation Chromosome Organization Demethylation Defense Response To Gram-positive Bacterium Regulation Of DNA Recombination	Meiosis I Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Cellular Response To Leucine Meiotic Nuclear Division Meiotic Cell Cycle Salivary Gland Cavitation Response To Leucine Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Tagcloud ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting
Tagcloud (Difference) ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting
Tagcloud (Intersection) ?