UBR2 and UBE2B

Number of citations of the paper that reports this interaction (PMID 14585983)
36

Data Source:
HPRD (in vivo)

		UBR2	UBE2B
Gene Name		ubiquitin protein ligase E3 component n-recognin 2	ubiquitin-conjugating enzyme E2B
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleoplasm Plasma Membrane	Chromatin Nuclear Chromatin XY Body Nucleus Replication Fork Cytoplasm Plasma Membrane HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Leucine Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Male Meiosis I Spermatogenesis Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine	Protein Polyubiquitination Response To Hypoxia In Utero Embryonic Development DNA Repair Postreplication Repair Maintenance Of Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Cellular Response To Insulin Stimulus Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Protein Stabilization Chiasma Assembly Protein Autoubiquitination Canonical Wnt Signaling Pathway Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: HIST1H2BG HIST2H2AC UBE2B UBE2H	19 interactors: BIRC2 CDKN1B CNOT4 CRMP1 CTNNB1 HIST2H2AC MED31 PCNA RAD18 RNF20 RNF40 TRIM45 UBA1 UBC UBR1 UBR2 UBR3 UBR5 UNC119
Entrez ID		23304	7320
HPRD ID		09853	01533
Ensembl ID		ENSG00000024048	ENSG00000119048
Uniprot IDs		B3KXG6 Q8IWV8	P63146
PDB IDs		3NY2 3NY3	1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Negative Regulation Of Histone Phosphorylation Positive Regulation Of Reciprocal Meiotic Recombination Maintenance Of Chromatin Silencing Positive Regulation Of Meiosis I Negative Regulation Of CAMP-mediated Signaling Chiasma Assembly Regulation Of Meiosis I Sperm Axoneme Assembly Histone H2A Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response In Mucosa Positive Regulation Of Meiotic Nuclear Division Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Postreplication Repair Regulation Of CAMP-mediated Signaling Axoneme Assembly Protein Modification By Small Protein Conjugation Protein Catabolic Process Synaptonemal Complex Organization Antibacterial Humoral Response Antimicrobial Humoral Response Chromatin Organization Mucosal Immune Response Protein K63-linked Ubiquitination Histone Lysine Demethylation Chromatin Silencing Histone Ubiquitination Histone Demethylation Protein Demethylation Protein Monoubiquitination Regulation Of Meiosis Protein Autoubiquitination Cellular Macromolecule Catabolic Process Reciprocal Meiotic Recombination Microtubule Bundle Formation Regulation Of Meiotic Cell Cycle Synapsis Homologous Chromosome Segregation Chromosome Organization Demethylation Defense Response To Gram-positive Bacterium Regulation Of DNA Recombination	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Response To Leucine Proteolysis Histone Ubiquitination Cellular Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Protein Polyubiquitination Response To Cadmium Ion Response To Leucine Histone H2B Ubiquitination Cellular Response To DNA Damage Stimulus Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Amino Acid Cell Cycle Process Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Histone Monoubiquitination Regulation Of Histone Modification Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organonitrogen Compound Positive Regulation Of Histone Methylation Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Protein Monoubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting
Tagcloud (Difference) ?		aav9 atrophy bioinformatics bona c26 cachectic cachexia cebpb coordinately diaphragm ebpbeta fide forkhead fos foxo foxo1 foxo3a foxo4 harvested hypothesize locomotor muscles networks outcompetes qrt sarcomere spared sparing wasting
Tagcloud (Intersection) ?