MLC1 and PRMT6

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		MLC1	PRMT6
Gene Name		megalencephalic leukoencephalopathy with subcortical cysts 1	protein arginine methyltransferase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Plasma Membrane Caveola Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Protein Complex Binding	Protein Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Transport Ion Transport Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Protein Oligomerization Cellular Response To Cholesterol Caveolin-mediated Endocytosis	Base-excision Repair Chromatin Organization Transcription, DNA-templated Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone H3-R2 Methylation Histone H4-R3 Methylation Negative Regulation Of Transcription, DNA-templated
Pathways			Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS			Intelligence ( 22449649) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		5 interactors: DAPK2 KDM1A MYLK PRMT6 TPT1	91 interactors: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C17orf82 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GRHL3 GSTCD GTPBP2 H3F3C HESX1 HIST1H4F HIST2H2AA3 HIST2H2BE HIST2H3A HIST2H3C HIST4H4 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LOXL4 MALT1 MED28 MLC1 MNDA MRPL38 MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PIAS1 PSMD11 PYCRL PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WBSCR27 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		23209	55170
HPRD ID		05800	10505
Ensembl ID		ENSG00000100427	ENSG00000198890
Uniprot IDs		B7Z659 F5H1B9 J3KQZ9 Q15049	Q96LA8
PDB IDs			4HC4
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Primitive Erythrocyte Differentiation Regulation Of Response To DNA Damage Stimulus Histone H3-R2 Methylation Aorta Smooth Muscle Tissue Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Anoikis Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Cellular Protein Modification Process Tonic Smooth Muscle Contraction Positive Regulation Of Megakaryocyte Differentiation Bleb Assembly Regulation Of Apoptotic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Regulation Of Cell Death Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Histone H4-R3 Methylation Negative Regulation Of Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Peptidyl-arginine N-methylation Hypotonic Response Regulation Of Intracellular Signal Transduction Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Muscle Structure Development Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Peptidyl-arginine Methylation Cellular Protein Metabolic Process Regulation Of Histone H3-K4 Methylation Response To Stimulus Negative Regulation Of Signal Transduction By P53 Class Mediator Aorta Morphogenesis Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Aorta Development Chromatin Modification Cellular Response To Osmotic Stress Regulation Of Hematopoietic Progenitor Cell Differentiation	Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Cell Cycle Cellular Metabolic Process Organelle Organization Oncogene-induced Cell Senescence Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Process Senescence-associated Heterochromatin Focus Assembly DNA Methylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Senescence Histone H4-K20 Demethylation Transcription, DNA-templated Cochlea Morphogenesis Chromatin Assembly Embryonic Organ Morphogenesis Cellular Macromolecule Biosynthetic Process Cell Aging RNA Biosynthetic Process Nucleosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Senescence Chromatin Organization Macromolecule Biosynthetic Process Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation
Tagcloud ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps myosin namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps myosin namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?