MLC1 and MYLK

Number of citations of the paper that reports this interaction (PMID 10092231)
140

Data Source:
BioGRID (enzymatic study)

		MLC1	MYLK
Gene Name		megalencephalic leukoencephalopathy with subcortical cysts 1	myosin light chain kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Plasma Membrane Caveola Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome	Stress Fiber Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Protein Complex Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	Transport Ion Transport Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Protein Oligomerization Cellular Response To Cholesterol Caveolin-mediated Endocytosis	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Actin Filament Organization Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DAPK2 KDM1A MYLK PRMT6 TPT1	13 interactors: ACTA1 ACTC1 CALM1 CAMK2G CTTN GOPC MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC
Entrez ID		23209	4638
HPRD ID		05800	02952
Ensembl ID		ENSG00000100427	ENSG00000065534
Uniprot IDs		B7Z659 F5H1B9 J3KQZ9 Q15049	B4DUE3 Q15746 Q6P2N0
PDB IDs			2CQV 2K0F 2YR3
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Primitive Erythrocyte Differentiation Regulation Of Response To DNA Damage Stimulus Histone H3-R2 Methylation Aorta Smooth Muscle Tissue Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Anoikis Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Cellular Protein Modification Process Tonic Smooth Muscle Contraction Positive Regulation Of Megakaryocyte Differentiation Bleb Assembly Regulation Of Apoptotic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Regulation Of Cell Death Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Histone H4-R3 Methylation Negative Regulation Of Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Peptidyl-arginine N-methylation Hypotonic Response Regulation Of Intracellular Signal Transduction Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Muscle Structure Development Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Peptidyl-arginine Methylation Cellular Protein Metabolic Process Regulation Of Histone H3-K4 Methylation Response To Stimulus Negative Regulation Of Signal Transduction By P53 Class Mediator Aorta Morphogenesis Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Aorta Development Chromatin Modification Cellular Response To Osmotic Stress Regulation Of Hematopoietic Progenitor Cell Differentiation	Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Innate Immune Response Fc Receptor Signaling Pathway Wound Healing Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity Response To Abiotic Stimulus Actin Filament-based Process Actin-myosin Filament Sliding Muscle Filament Sliding Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Response To Wounding Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cellular Component Assembly Epidermal Growth Factor Receptor Signaling Pathway Anatomical Structure Development Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Actin-mediated Cell Contraction Immune Response Regulation Of Kinase Activity Protein Phosphorylation Blood Coagulation Hemostasis Defense Response Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Peptidyl-serine Autophosphorylation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Muscle Contraction
Tagcloud ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps myosin namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?		myosin