MLC1 and TPT1

Number of citations of the paper that reports this interaction (PMID 12149273)
28

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MLC1	TPT1
Gene Name		megalencephalic leukoencephalopathy with subcortical cysts 1	tumor protein, translationally-controlled 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Plasma Membrane Caveola Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome	Extracellular Space Nucleus Cytoplasm Multivesicular Body Tubulin Complex Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Protein Complex Binding	Calcium Ion Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Transport Ion Transport Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Protein Oligomerization Cellular Response To Cholesterol Caveolin-mediated Endocytosis	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DAPK2 KDM1A MYLK PRMT6 TPT1	25 interactors: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1D FANCA IKBKG LIG4 MCL1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A
Entrez ID		23209	7178
HPRD ID		05800	15979
Ensembl ID		ENSG00000100427	ENSG00000133112
Uniprot IDs		B7Z659 F5H1B9 J3KQZ9 Q15049	P13693 Q8TBK7
PDB IDs			1YZ1 2HR9 3EBM
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Primitive Erythrocyte Differentiation Regulation Of Response To DNA Damage Stimulus Histone H3-R2 Methylation Aorta Smooth Muscle Tissue Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Anoikis Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Cellular Protein Modification Process Tonic Smooth Muscle Contraction Positive Regulation Of Megakaryocyte Differentiation Bleb Assembly Regulation Of Apoptotic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Regulation Of Cell Death Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Histone H4-R3 Methylation Negative Regulation Of Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Peptidyl-arginine N-methylation Hypotonic Response Regulation Of Intracellular Signal Transduction Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Muscle Structure Development Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Peptidyl-arginine Methylation Cellular Protein Metabolic Process Regulation Of Histone H3-K4 Methylation Response To Stimulus Negative Regulation Of Signal Transduction By P53 Class Mediator Aorta Morphogenesis Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Aorta Development Chromatin Modification Cellular Response To Osmotic Stress Regulation Of Hematopoietic Progenitor Cell Differentiation	Regulation Of Response To DNA Damage Stimulus Cell Communication By Electrical Coupling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stimulus Cellular Response To DNA Damage Stimulus Response To Organic Cyclic Compound Response To Glycoside Apoptotic Process Regulation Of The Force Of Heart Contraction Response To Radiation Programmed Cell Death Positive Regulation Of Mitotic Cell Cycle Cell Death Death Response To Steroid Hormone Response To Abiotic Stimulus Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Stress Sodium Ion Export From Cell Response To Lipid Regulation Of Signaling Cardiac Muscle Contraction Response To Stimulus Regulation Of Heart Contraction Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Sodium Ion Export Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Potassium Ion Homeostasis Cellular Response To Steroid Hormone Stimulus Neuron Death Cell Cycle Heart Contraction Cellular Response To Organic Cyclic Compound Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Cellular Localization Cellular Response To Lipid Regulation Of Cardiac Muscle Contraction Regulation Of Neurogenesis Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Apoptotic Process Muscle Contraction Regulation Of Cellular Process Negative Regulation Of Mitotic Cell Cycle Cellular Localization
Tagcloud ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps myosin namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	2o2 activating adds antioxidant avenue challenge chemoresistance complexity contain continuously correlation differentially direct diverse element existed fact lung maintains minimize mutated network open p53 promote responsive reversion stability upregulates
Tagcloud (Difference) ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps myosin namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	2o2 activating adds antioxidant avenue challenge chemoresistance complexity contain continuously correlation differentially direct diverse element existed fact lung maintains minimize mutated network open p53 promote responsive reversion stability upregulates
Tagcloud (Intersection) ?