MLC1

Description		modulator of VRAC current 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Astrocyte End-foot
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases		Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		Acne (severe) ( 24927181) Body mass index (adult) ( 28430825) Femur bone mineral density x serum urate levels interaction ( 34046847)
Novel Interacting Genes		2 novel interacting genes: IRF8 NAT14
Interacting Genes		7 interacting genes: DAPK2 KDM1A MYLK PRMT6 ROCK1 SNCA TPT1
Entrez ID		23209
HPRD ID		05800
Ensembl ID		ENSG00000100427
Uniprot IDs		B7Z2T9 Q15049
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Recycling Bleb Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Smooth Muscle Contraction Phosphorylation Protein Phosphorylation Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Transferase Activity Regulation Of Endocytosis Rho-dependent Protein Serine/threonine Kinase Activity Regulation Of Amide Metabolic Process Negative Regulation Of Apoptotic Process Tau Protein Binding Negative Regulation Of Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Autophagy Negative Regulation Of Programmed Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ectoderm Development Regulation Of Apoptotic Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Eosinophil Chemotaxis Positive Regulation Of Eosinophil Migration Autophagosome Lumen Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Response To Type II Interferon Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Neuron Apoptotic Process Regulation Of Signal Transduction Mesenchymal Cell Differentiation Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy
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