MLC1 and DAPK2

Number of citations of the paper that reports this interaction (PubMedID 10376525)
0

Data Source:
HPRD (in vitro)

		MLC1	DAPK2
Description		modulator of VRAC current 1	death associated protein kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Astrocyte End-foot	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Neutrophil Migration Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Dependence Receptors in the absence of ligand
Drugs			Fostamatinib
Diseases		Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		Acne (severe) ( 24927181) Body mass index (adult) ( 28430825) Femur bone mineral density x serum urate levels interaction ( 34046847)	Arterial stiffness index ( 31235810) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) HDL cholesterol levels ( 32203549) Platelet distribution width ( 27863252) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		7 interacting genes: DAPK2 KDM1A MYLK PRMT6 ROCK1 SNCA TPT1	6 interacting genes: APP CAMK2A CCDC91 FAM9B MLC1 TGFBR1
Entrez ID		23209	23604
HPRD ID		05800	09905
Ensembl ID		ENSG00000100427	ENSG00000035664
Uniprot IDs		B7Z2T9 Q15049	Q1RMF4 Q9UIK4
PDB IDs			1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW 7A6R 7A6Y
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Recycling Bleb Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Smooth Muscle Contraction Phosphorylation Protein Phosphorylation Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Transferase Activity Regulation Of Endocytosis Rho-dependent Protein Serine/threonine Kinase Activity Regulation Of Amide Metabolic Process Negative Regulation Of Apoptotic Process Tau Protein Binding Negative Regulation Of Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Autophagy Negative Regulation Of Programmed Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ectoderm Development Regulation Of Apoptotic Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Eosinophil Chemotaxis Positive Regulation Of Eosinophil Migration Autophagosome Lumen Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Response To Type II Interferon Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Neuron Apoptotic Process Regulation Of Signal Transduction Mesenchymal Cell Differentiation Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy	Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Response To Cholesterol Membrane Raft Peptidyl-serine Phosphorylation Endosome Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Peptidyl-threonine Autophosphorylation Protein Phosphorylation Positive Regulation Of Hepatocyte Apoptotic Process Identical Protein Binding Regulation Of Cell Migration Regulation Of Apoptotic Signaling Pathway Phosphorylation Protein Serine/threonine Kinase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Locomotion Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cell Motility Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Autophosphorylation Protein Kinase Activity Regulation Of Endocannabinoid Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Negative Regulation Of Canonical Wnt Signaling Pathway
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