MLC1 and DAPK2

Number of citations of the paper that reports this interaction (PMID 10376525)
22

Data Source:
HPRD (in vitro)

		MLC1	DAPK2
Gene Name		megalencephalic leukoencephalopathy with subcortical cysts 1	death-associated protein kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Plasma Membrane Caveola Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome	Cytoplasm Cytoplasmic Vesicle Autophagic Vacuole Lumen
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity Protein Complex Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding
	Biological Process	Transport Ion Transport Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Protein Oligomerization Cellular Response To Cholesterol Caveolin-mediated Endocytosis	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DAPK2 KDM1A MYLK PRMT6 TPT1	5 interactors: APP CAMK2A FAM9B MLC1 TGFBR1
Entrez ID		23209	23604
HPRD ID		05800	09905
Ensembl ID		ENSG00000100427	ENSG00000035664
Uniprot IDs		B7Z659 F5H1B9 J3KQZ9 Q15049	Q9UIK4
PDB IDs			1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Primitive Erythrocyte Differentiation Regulation Of Response To DNA Damage Stimulus Histone H3-R2 Methylation Aorta Smooth Muscle Tissue Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Anoikis Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Cellular Protein Modification Process Tonic Smooth Muscle Contraction Positive Regulation Of Megakaryocyte Differentiation Bleb Assembly Regulation Of Apoptotic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Hormone Biosynthetic Process Regulation Of Cell Death Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Histone H4-R3 Methylation Negative Regulation Of Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Peptidyl-arginine N-methylation Hypotonic Response Regulation Of Intracellular Signal Transduction Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Muscle Structure Development Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Arginine Methylation Peptidyl-arginine Methylation Cellular Protein Metabolic Process Regulation Of Histone H3-K4 Methylation Response To Stimulus Negative Regulation Of Signal Transduction By P53 Class Mediator Aorta Morphogenesis Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Aorta Development Chromatin Modification Cellular Response To Osmotic Stress Regulation Of Hematopoietic Progenitor Cell Differentiation	Response To Cholesterol Positive Regulation Of Transport Peptidyl-serine Phosphorylation Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Localization Cell Death Death Collateral Sprouting In Absence Of Injury Positive Regulation Of Intracellular Transport Protein Phosphorylation Regulation Of Binding Caveolin-mediated Endocytosis Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Parathyroid Gland Development Regulation Of Response To Osmotic Stress Extracellular Matrix Organization Extracellular Structure Organization Neuron Remodeling Phosphorylation Cellular Response To Organic Substance Endothelial Cell Activation Regulation Of Intracellular Transport Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Cholesterol Regulation Of SMAD Protein Import Into Nucleus Immune System Process Cellular Response To Sterol Germ Cell Migration Cellular Copper Ion Homeostasis Pharyngeal System Development Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Regulation Of Growth Positive Regulation Of Cell Death Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps myosin namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	ablation avenue bullet correspondingly dr dr4 dr5 druggable hailed imminently impetuous indeed issues kill killing magic modulator offer overcome proapoptotic reappraised sensitisation signalling targetable tolerated trail trigger unfortunately usable
Tagcloud (Difference) ?		adopted aerobic autocrine cardiomyocyte cardiomyocytes chains chemically consequent contractile contractility elucidated identifies identity isoform metalloproteinases mlc2 mmp mmps myosin namely paracrine protected reperfusion sarcomeric scramble sirna subjected transfection turnover	ablation avenue bullet correspondingly dr dr4 dr5 druggable hailed imminently impetuous indeed issues kill killing magic modulator offer overcome proapoptotic reappraised sensitisation signalling targetable tolerated trail trigger unfortunately usable
Tagcloud (Intersection) ?