WDFY3 and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		WDFY3	PRMT6
Description		WD repeat and FYVE domain containing 3	protein arginine methyltransferase 6
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Nuclear Envelope Nucleoplasm Nucleolus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Inclusion Body PML Body Axon Nuclear Membrane Atg12-Atg5-Atg16 Complex Cell Projection Perikaryon	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Lipid Binding Metal Ion Binding	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Autophagy Macroautophagy Aggrephagy	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Monocyte percentage of white cells ( 32888494) Oropharynx cancer ( 27749845)	Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		16 interacting genes: ATG5 BTG3 CEP76 GABARAPL1 GABARAPL2 GRB2 MAP1LC3C MDFI PRMT1 PRMT6 RABGAP1L STAT3 SUV39H1 TNS2 TRIM39 ZBTB44	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		23001	55170
HPRD ID		10304	10505
Ensembl ID		ENSG00000163625	ENSG00000198890
Uniprot IDs		Q8IZQ1	Q96LA8
PDB IDs		3WIM 6W9N	4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Mitophagy Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Cellular Response To Stress Response To Nutrient Levels Histone Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Macroautophagy Autophagosome Maturation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Vacuole Organization Autophagosome Membrane Protein-arginine N-methyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Aggrephagy Response To Stress GABA Receptor Binding Autophagy Negative Regulation Of Protein Metabolic Process Phospholipid Binding Histone H3 Methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Protein-containing Complex Disassembly Negative Regulation Of Catabolic Process Organelle Assembly Methyltransferase Activity Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation DNA Damage Response Beta-tubulin Binding Protein Sequestering Activity Methylation Cytoplasmic Vesicle Guanyl-nucleotide Exchange Factor Adaptor Activity GATOR1 Complex Binding Histone H2AR3 Methyltransferase Activity Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Myeloid Cell Differentiation Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus
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